The Poor Prognostic Stigma of Hepatic Superscan on 18F-FDG PET Imaging
PDF
Cite
Share
Request
Interesting Image
VOLUME: 34 ISSUE: 2
P: 149 - 151
June 2025

The Poor Prognostic Stigma of Hepatic Superscan on 18F-FDG PET Imaging

Mol Imaging Radionucl Ther 2025;34(2):149-151
1. King Hussein Cancer Center (KHCC), Department of Nuclear Medicine and PET/CT, Al-Jubeiha, Amman, Jordan
2. University of Jordan, Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, Amman, Jordan
No information available.
No information available
Received Date: 15.08.2024
Accepted Date: 08.09.2024
Online Date: 03.06.2025
Publish Date: 03.06.2025
PDF
Cite
Share
Request

Abstract

Pancreatic exocrine carcinoma (PEC) is a lethal malignancy with high mortality rates because of its aggressive nature and frequent late-stage diagnosis. When histopathological diagnosis becomes unfeasible because of patient deterioration, clinicians must rely on clinical, biochemical, and radiological findings. This case report describes a 78-year-old woman with aggressive PEC visualized through 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography. The imaging revealed an intensely hypermetabolic head mass, hepatic superscan, and hypermetabolic abdominal lymphadenopathy. Despite strong clinical indicators suggesting stage IV PEC, rapid disease progression and patient demise precluded histopathological confirmation, emphasizing the poor prognosis associated with hepatic superscan in this context.

Keywords:
Pancreatic carcinoma, hepatic superscan, fulminant metastasis, 18F-FDG, PET/CT
Ethic
Informed Consent: The patient consent was obtained.

Authorship Contributions

Surgical and Medical Practices: D.A., M.J., A.A., Concept: D.A., M.J., A.A., Design: D.A., M.J., A.A., Data Collection or Processing: D.A., M.J., A.A., Analysis or Interpretation: D.A., A.A., Literature Search: M.J., A.A., Writing: D.A., A.A.
Conflict of Interest: No conflicts of interest were declared by the authors.
Financial Disclosure: The authors declare that this study has received no financial support.

References

1
Basu S, Nair N. Unusually elevated liver radioactivity on F-18 FDG PET in Hodgkin’s disease: hepatic ‘superscan’. Clin Nucl Med. 2004;29:626-628.
2
Abdlkadir AS, Al-Adhami D, Alsyouf B, Alhouwari R, Al-Rasheed U, Jaber O, Mohamad I, Al-Ibraheem A. Hepatic Superscan in Medullary Thyroid Carcinoma: A Rare Presentation in [F]FDG PET/CT. Nucl Med Mol Imaging. 2024;58:147-149.
3
Abdlkadir AS, Almasri N, Estrada E, Fani Bozkurt M, Al-Ibraheem A. 18 F-FDG PET/CT Unveils Coexistent Myelomatous Hepatosplenic and Thyroid Cartilage Involvement : A Rare Presentation in Multiple Myeloma. Clin Nucl Med. 2024;49:897-898.
4
Taneja S, Achong DM. Hepatic superscan on PET/CT due to Richter’s transformation of chronic lymphocytic leukemia. Clin Nucl Med. 2010;35:644-645.
5
Yang G, Nie P, Wang Z, Xing X. (18)F-FDG hepatic superscan caused by a non-germinal center subtype of diffuse large B-cell lymphoma. Eur J Nucl Med Mol Imaging. 2016;43:1928.