Tc-99m-MDP Uptake in Extraosseous Metastases From Ovarian Papillary Serous Adenocarcinoma
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Tc-99m-MDP Uptake in Extraosseous Metastases From Ovarian Papillary Serous Adenocarcinoma

Mol Imaging Radionucl Ther 0;0(0):undefined-undefined
1. All India Institute of Medical Sciences Department of Nuclear Medicine, Bhubaneswar, India
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Abstract

The uptake of Tc-99m-uptake of Tc-99m-methylene diphosphonate (MDP) on bone scintigraphy can be seen at sites other than bone in a varying number of benign and malignant conditions. Extraosseous metastatic calcifications can occur in ovarian papillary serous adenocarcinoma (PSAC). These extraosseous calcifications show Tc-99m-MDP uptake. We report a case of a female in her sixties who had a previous history of PSAC of the ovary. The patient had undergone neoadjuvant chemotherapy (NACT) followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy. She also received adjuvant chemotherapy. Tc-99m-MDP bone scan was performed post chemotherapy because the patient complained of lower backache. The scan showed increased uptake in the lower thoracic and lumbar vertebral regions. However, single-photon emission computed tomography/computed tomography (CT) localizes the uptake to metastatic calcified peritoneal deposits. Further 18F-fluorodeoxyglucose positron emission tomography/CT confirmed widespread peritoneal and omental metastatic disease with increased uptake.

Keywords: Tc-99m-MDP, metastases, ovarian papillary serous adenocarcinoma

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