ABSTRACT
18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) plays a pivotal role in the staging, restaging, and surveillance of various bone tumors, including plasmacytomas and osteosarcomas. Solitary plasmacytomas most frequently occur in the bones and are primarily treated with either surgery or radiotherapy. Radiation-induced osteosarcomas (RIOS) usually develop after a median interval of 11 years between radiation and sarcoma presentation. However, these can rarely present with a short latent period of 4 years or even lesser. In such cases, whole-body imaging plays a vital role in the early detection and management of RIOS. Herein, we present the case of a 29-year-old female patient with solitary plasmacytoma undergoing a follow-up whole-body 18F-FDG PET/CT, which revealed metastatic RIOS after a short latent period.
Keywords:
Solitary plasmacytoma, 18F-FDG PET/CT, radiation-induced osteosarcoma
References
1Ali SA, Hamed MAE. The diagnostic efficacy of whole body 18F-FDG PET CT in detection of unexpected second primary malignancy in cancer patients. EJRNM 2017;48:671-676.
2Zhang X, Guan Z. PET/CT in the diagnosis and prognosis of osteosarcoma. Front Biosci (Landmark Ed) 2018;23:2157-2165.
3Nanni C, Rubello D, Zamagni E, Castellucci P, Ambrosini V, Montini G, Cavo M, Lodi F, Pettinato C, Grassetto G, Franchi R, Gross MD, Fanti S. 18F-FDG PET/CT in myeloma with presumed solitary plasmocytoma of bone. In Vivo 2008;22:513-517.
4Rustemeyer P, Micke O, Blasius S, Peters PE. Radiation-induced malignant mesenchymoma of the chest wall following treatment for breast cancer. Br J Radiol 1997;70:424-426.
5Tsuda Y, Ogura K, Shinoda Y, Kobayashi H, Tanaka S, Kawai A. The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences. BMC Cancer 2018;18:614.
6Mavrogenis AF, Pala E, Guerra G, Ruggieri P. Post-radiation sarcomas. Clinical outcome of 52 Patients. J Surg Oncol 2012;105:570-576.