ABSTRACT
There have been several studies on the clinical outcomes of Radium-223 treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) who may have an increased risk of hematologic comorbidities. To the best of our knowledge, this is the first study to explore the potential bone marrow adverse effects (AEs) of Radium-223 administered with specific drugs used for hematologic conditions, such as polycythemia vera (PV). We report the case of a patient with mCRPC who was administered a combined treatment of Radium-223 and hydroxyurea for PV, aiming to support clinicians in predicting eventual AEs.
Prostate cancer (PCa) represents the second most prevalent cancer in men and the fifth cause of cancer-related mortality worldwide (1). Bone secondary tumor localizations are the most frequent expression of advanced PCa, representing the cause of morbidity and mortality and determining a poor prognosis. Several studies have been provided concerning the clinical outcomes of Radium-223 treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) (2,3). Moreover, patients with mCRPC could suffer from hematologic comorbidities. Notably, to our knowledge, there are no studies involving the use of Radium-223 in patients with mCRPC and preexisting hematological conditions, such as polycythemia vera (PV), a chronic myeloproliferative disorder. Thus, studies that could support clinicians to predict eventual adverse effects (AEs) in these cases are warranted.