E-ISSN: 2147-1959
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial 18F-FDG PET/CT Imaging
PDF
Cite
Share
Request
Interesting Images
VOLUME: 27 ISSUE: 1
P: 41-47
February 2018

Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial 18F-FDG PET/CT Imaging

Mol Imaging Radionucl Ther 2018;27(1):41-47
DOI: 10.4274/mirt.07088
William Makis 1
Anthony Ciarallo 2
Stephan Probst 3
1. Cross Cancer Institute, Department of Diagnostic Imaging, Edmonton, Canada
2. McGill University Health Centre, Department of Nuclear Medicine, Montreal, Canada
3. Jewish General Hospital, Department of Nuclear Medicine, Montreal, Canada
No information available.
No information available
Received Date: 31.12.2016
Accepted Date: 15.10.2017
Publish Date: 22.01.2018
PDF
Cite
Share
Request

ABSTRACT

A 67-year-old female patient with no prior history of benign thyroid disease was diagnosed with primary thyroid lymphoma and was staged with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). She was treated with chemotherapy and external beam radiation therapy, and a follow-up PET/CT showed significant reduction in the size of the thyroid lymphoma with persistent intense 18F-FDG uptake, which was interpreted as partial response to therapy. However, two subsequent PET/CT studies showed no change in the persistent intense 18F-FDG uptake in the thyroid and a biopsy confirmed the presence of thyroiditis with no evidence of residual lymphoma. Follow-up PET/CTs performed over the subsequent three years showed stable intensely 18F-FDG avid thyroiditis with no evidence of lymphoma recurrence. We present the imaging characteristics of a long term radiation treatment induced thyroiditis mimicking 18F-FDG avid residual disease on PET/CT.

Keywords:
Thyroid lymphoma, thyroiditis, pitfall, artifact, 18F-FDG, PET

Ethics

Informed Consent: All subjects in the study gave written informed consent or the institutional review board waived the need to obtain informed consent.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: W.M., A.C., S.P., Concept: W.M., Design: W.M., Data Collection or Processing: W.M., A.C., S.P., Analysis or Interpretation: W.M., A.C., S.P., Literature Search: W.M., A.C., S.P., Writing: W.M.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.