E-ISSN: 2147-1959
Pneumonia with Intense <sup>68</sup>Ga-FAPI Uptake Mimicking Metastasis on <sup>68</sup>Ga-FAPI PET/CT in a Patient with Rectal Cancer
PDF
Cite
Share
Request
Interesting Image
VOLUME: 32 ISSUE: 3
P: 237-238
October 2023

Pneumonia with Intense 68Ga-FAPI Uptake Mimicking Metastasis on 68Ga-FAPI PET/CT in a Patient with Rectal Cancer

Mol Imaging Radionucl Ther 2023;32(3):237-238
DOI: 10.4274/mirt.galenos.2023.07830
Özge Erol Fenercioğlu 1
Ediz Beyhan 1
Nilay Şengül Samancı 2
Tevfik Fikret Çermik 1
Nurhan Ergül 1
1. University of Health Sciences Türkiye, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Türkiye
2. University of Health Sciences Türkiye, İstanbul Training and Research Hospital, Clinic of Medical Oncology, İstanbul, Türkiye
No information available.
No information available
Received Date: 18.07.2022
Accepted Date: 04.02.2023
Publish Date: 20.10.2023
PDF
Cite
Share
Request

ABSTRACT

A 70-year-old man with newly diagnosed rectum adenocarcinoma was referred to 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging, and 68Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/CT for ongoing trial. Both 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT showed intense uptake in the primary rectal tumor, and also in nodular areas in the right lung. Due to intense 68Ga-FAPI-04 and 18F-FDG uptake, the lung lesions were considered as metastases. However the lesions were reduced in size on CT after 20 days antibiotherapy and diagnosed as pneumonia.

References

1
Kratochwil C, Flechsig P, Lindner T, Abderrahim L, Altmann A, Mier W, Adeberg S, Rathke H, Röhrich M, Winter H, Plinkert PK, Marme F, Lang M, Kauczor HU, Jäger D, Debus J, Haberkorn U, Giesel FL. 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer. J Nucl Med 2019;60:801-805.
2
Dendl K, Koerber SA, Kratochwil C, Cardinale J, Finck R, Dabir M, Novruzov E, Watabe T, Kramer V, Choyke PL, Haberkorn U, Giesel FL. FAP and FAPI-PET/CT in Malignant and Non-Malignant Diseases: A Perfect Symbiosis? Cancers (Basel) 2021;13:4946.
3
Erol Fenercioğlu Ö, Beyhan E, Ergül N, Arslan E, Çermik TF. 18F-FDG PET/CT and 68Ga-FAPI-4 PET/CT Findings of Bilateral Knee Osteoarthritis in a Patient With Uveal Malignant Melanoma. Clin Nucl Med 2022;47:e144-e146.
4
Tang W, Wu J, Yang S, Wang Q, Chen Y. Organizing Pneumonia With Intense 68Ga-FAPI Uptake Mimicking Lung Cancer on 68Ga-FAPI PET/CT. Clin Nucl Med 2022;47:223-225.
5
Liu H, Wang Y, Zhang W, Cai L, Chen Y. Elevated 68Ga-FAPI Activity in Splenic Hemangioma and Pneumonia. Clin Nucl Med 2021;46:694-696.
6
Zheng S, Lin R, Chen S, Zheng J, Lin Z, Zhang Y, Xue Q, Chen Y, Zhang J, Lin K, You X, Yao S, Miao W. Characterization of the benign lesions with increased 68Ga-FAPI-04 uptake in PET/CT. Ann Nucl Med 2021;35:1312-1320.
7
Pang Y, Zhao L, Luo Z, Hao B, Wu H, Lin Q, Sun L, Chen H. Comparison of 68Ga-FAPI and 18F-FDG Uptake in Gastric, Duodenal, and Colorectal Cancers. Radiology 2021;298:393-402.
8
Çermik TF, Ergül N, Yılmaz B, Mercanoğlu G. Tumor Imaging With 68Ga-DOTA-FAPI-04 PET/CT: Comparison With 18F-FDG PET/CT in 22 Different Cancer Types. Clin Nucl Med 2022;47:e333-e339.