PET/CT Identifies Pubic Melorheostosis with High 68Ga-PSMA Uptake in a Patient with Prostate Cancer

Deya Aldeen Sweedat; Ahmed Saad Abdlkadir; Akram Al-Ibraheem

doi:10.4274/mirt.galenos.2026.62144

Abstract

Melorheostosis, a rare benign bone disorder marked by cortical thickening and irregular hyperostosis, typically affects peripheral bones but can also involve the axial skeleton. Though various molecular imaging radiotracers have been used to evaluate this condition, there are no previous reports of positive⁶⁸Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (⁶⁸Ga-PSMA PET/CT) findings in melorheostosis. This case presents a 70-year-old man with metastatic prostate cancer whose ⁶⁸Ga-PSMA PET/CT scan revealed intense ⁶⁸Ga-PSMA uptake in pubic melorheostosis seen on magnetic resonance imaging. The case highlights the possibility of ⁶⁸Ga-PSMA-avid melorheostosis and suggests ⁶⁸Ga-PSMA PET/CT may have a role in the evaluation of melorheostosis.

Keywords:

Melorheostosis, 68Ga-PSMA, diagnostic challenge, PET/CT, prostate cancer, false positive

Figure 1

Ethics

Informed Consent: The patient provided written informed consent.

Authorship Contributions

Surgical and Medical Practices: D.A.S., A.S.A., A.A-I., Concept: D.A.S., A.S.A., A.A-I., Design: D.A.S., A.S.A., A.A-I., Data Collection or Processing: D.A.S., A.S.A., A.A-I., Literature Search: D.A.S., A.S.A., A.A-I., Writing: D.A.S., A.S.A., A.A-I.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support.

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