Penile Metastasis from Prostate Cancer: Detection on 18F-PSMA-1007 PET/CT
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1 August 2025

Penile Metastasis from Prostate Cancer: Detection on 18F-PSMA-1007 PET/CT

Mol Imaging Radionucl Ther. Published online 1 August 2025.
1. University Hospitals Bristol and Weston NHS Foundation Trust, Clinic of Radiology, Bristol, UK
2. Cobalt Medical Charity, Cheltenham, UK
3. Cairo University Faculty of Medicine, Department of Clinical Oncology and Nuclear Medicine, Cairo, Egypt
4. Gloucestershire Hospitals NHS Foundation Trust, Clinic of Radiology,  Gloucestershire, UK
5. Cranfield Forensic Institute, Cranfield University, Wiltshire, UK
No information available.
No information available
Received Date: 03.07.2024
Accepted Date: 20.01.2025
E-Pub Date: 01.08.2025
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Abstract

A 74-year-old man with a history of prostate cancer and rising prostate-specific antigen underwent 18F-prostate specific membrane antigen (PSMA)-1007 positron emission tomography/computed tomography for investigation of oligometastatic disease. There was evidence of PSMA avid local recurrence findings with pelvic and retroperitoneal nodal metastases and skeletal deposits. Although rare and could easily be mistaken for contamination, a small penile metastasis was found. This is associated with poor prognosis and could impact further management. This case highlights the importance of a detailed review of the penis, to ensure differentiation between urinary activity and pathological uptake.

Keywords:
18F-PSMA-1007 positron emission tomography/computed tomography, prostate cancer, penile metastasis

Ethics

Informed Consent: The patient has given permission for anonymised imaging and clinical information to be used for teaching, audit, research and publications including social media.

Authorship Contributions

Surgical and Medical Practices: A.N, J.S, I.L, Concept: A.N, J.S, I.L, Design: H.K, A.N, J.S, I.L, Data Collection or Processing: H.K, A.N, J.S, I.L, Analysis or Interpretation: H.K, A.N, J.S, I.L, Literature Search: H.K., Writing: H.K, A.N, J.S, I.L.
Conflict of Interest: No conflicts of interest were declared by the authors.
Financial Disclosure: The authors declare that this study has received no financial support.

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