E-ISSN: 2147-1959
Oncological Follow-up with 2-[<sup>18</sup>F]-FDG PET/CT in Li-Fraumeni Syndrome
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VOLUME: 30 ISSUE: 2
P: 110-112
June 2021

Oncological Follow-up with 2-[18F]-FDG PET/CT in Li-Fraumeni Syndrome

Mol Imaging Radionucl Ther 2021;30(2):110-112
DOI: 10.4274/mirt.galenos.2020.33255
Marylin Acuña Hernandez 1
Iván Fabricio Vega Gonzalez 2
Lina López Vélez 2
Catalina Melo Arango 3
1. Autonomous University of Bucaramanga (UNAB), Department of Nuclear Medicine, Bucaramanga, Santander, Colombia
2. Las Américas Clinic Auna, Department of Nuclear Medicine, Medellin, Antioquia, Colombia
3. Las Américas Clinic Auna, Department of Radiology, Medellin, Antioquia, Colombia
No information available.
No information available
Received Date: 10.11.2019
Accepted Date: 24.04.2020
Publish Date: 03.06.2021
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ABSTRACT

Li-Fraumeni syndrome is a rare disorder caused by abnormalities of the tumor-suppressor protein P53 gene. We present the case of a 26-years-old female diagnosed with bilateral ductal carcinoma. The genetic panel for breast cancer gene 1 (BRCA1) and BRCA2 mutations was negative and positive heterozygous germline tumor protein P53 gene mutations, considering Li-Fraumeni syndrome. A 2-[18F]-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) was used for postsurgical staging to show the right lung hypermetabolic nodule. A lobectomy was accomplished, and histopathology reported pulmonary adenocarcinoma. A year later, oncological follow-up was conducted with 2-[18F]-FDG PET/CT without evidence of abnormalities.

References

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Aedma SK, Kasi A. Li-Fraumeni Syndrome. 2020 Nov 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021.
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McBride KA, Ballinger ML, Killick E, Kirk J, Tattersall MH, Eeles RA, Thomas DM, Mitchell G. Li-Fraumeni syndrome: cancer risk assessment and clinical management. Nat Rev Clin Oncol 2014;11:260-271.
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Nogueira ST, Lima EN, Nóbrega AF, Torres Ido C, Cavicchioli M, Hainaut P, Achatz MI. (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome. Front Oncol 2015;19;5:38.