Molecular Perspectives on Meningioma with Osseous Infiltration Revealed by 68Ga-DOTA TOC PET-CT

Sharjeel Usmani; Anjali Jain; Khulood Al Riyami; Syed Furqan Hashmi; Jamsari Khalid; Subhash Kheruka

doi:10.4274/mirt.galenos.2024.99267

Abstract

Meningiomas express the somatostatin receptor (SSTR). The utilization of SSTR ligands, specifically Gallium-68 (⁶⁸Ga) isotope, a radioactive isotope (⁶⁸Ga)-DOTA-labeled peptides, has demonstrated exceptional diagnostic precision for the detection of meningiomas, primarily due to the absence of normal brain and bone activity. We report a case of a 48-year-old woman with sphenoid wing meningioma who underwent ⁶⁸Ga-DOTA TOC positron emission tomography (PET) for tumor delineation. ⁶⁸Ga-DOTA TOC PET shows SSTR-avid meningioma in the right sphenoid/anterior temporal region with significant hyperostosis with high expression of SSTR in the bone. ⁶⁸Ga-DOTA TOC uptake in the hyperostosis signifies bone infiltration rather than reactive changes. ⁶⁸Ga-DOTA PET provides a better assessment of osseous involvement and provides additional information in terms of meningioma extent and planning for further management.

Keywords:

68Ga-DOTA, positron emission tomography/computed tomography, meningioma, SSTR, hyperostosis

Figure 1, 2

Ethics

Informed Consent: Patient consent was not required for this study.

Authorship Contributions

Surgical and Medical Practices: S.F.H., J.K., Concept: S.U., A.J., K.A.R., S.F.H., S.K., Design: S.U., A.J., S.K., J.K., Data Collection or Processing: S.U., J.K., Analysis or Interpretation: S.U., S.F.H., A.J., K.A.R., S.K., Literature Search: S.U., Writing: S.U., A.J., K.A.R.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support

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