E-ISSN: 2147-1959
Masking Effect of Radiopharmaceutical Dose Extravasation During Injection on Myocardial Perfusion Defects During SPECT Myocardial Perfusion Imaging: A Potential Source of False Negative Result
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VOLUME: 27 ISSUE: 3
P: 141-143
October 2018

Masking Effect of Radiopharmaceutical Dose Extravasation During Injection on Myocardial Perfusion Defects During SPECT Myocardial Perfusion Imaging: A Potential Source of False Negative Result

Mol Imaging Radionucl Ther 2018;27(3):141-143
DOI: 10.4274/mirt.88942
Mohsen Qutbi
1. Department of Nuclear Medicine, Taleghani Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
No information available.
No information available
Received Date: 15.02.2018
Accepted Date: 24.07.2018
Publish Date: 09.10.2018
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ABSTRACT

Proper interpretation of SPECT myocardial perfusion imaging (MPI) is primarily based on strict adherence to standard procedural protocols from patient preparation to image processing and display. Inadvertent faulty injection of the radiopharmaceutical and, consequently, dose extravasation during SPECT MPI is a more important issue than that in any other diagnostic scintigraphic procedure. As it can be considered as a major source of false negative result, clinician’s awareness of this problem during interpretation is of great importance. In some occasions, no local clinical signs or image findings may be available to the interpreter to be aware of dose extravasation to adopt a suitable approach. Herein, we present a case with dose extravasation during stress phase, which is repeated another day with the same protocol, and the potential effects of dose extravasation on SPECT myocardial perfusion images from different aspects and useful image findings as hints are provided.

References

1
Taillefer R. The clinical importance of accurate measurement of injected doses for radionuclide myocardial perfusion imaging. J Nucl Cardiol 2016;23:265-267.
2
Travin MI. Pitfalls and Limitations of Radionuclide and Hybrid Cardiac Imaging. Semin Nucl Med 2015;45:392-410.
3
Image quality in nuclear medicine. In: Cherry SR, Sorenson JA, Phelps ME (eds). Physics in nuclear medicine, Philadelphia, Elsevier Saunders, 2012;233-251.
4
Depuey EG. Image artifacts. In: Iskandrian AE, (ed). Atlas of nuclear cardiology: imaging companion to Braunwald’s heart disease. Philadelphia, Elsevier Saunders, 2012;56-95.
5
Strauss HW, Miller DD, Wittry MD, Cerqueira MD, Garcia EV, Iskandrian AS, Schelbert HR, Wackers FJ. Procedure guideline for myocardial perfusion imaging. Society of Nuclear Medicine. J Nucl Med 1998;39:918-923.
6
Shih WJ, Collins J, Kiefer V. Visualization in the ipsilateral lymph nodes secondary to extravasation of a bone-imaging agent in the left hand: a case report. J Nucl Med Technol 2001;29:154-155.