Abstract
A rare tumor, intestinal-type adenocarcinoma (ITAC), accounts for 8-25% of all sinonasal malignancies. The tumor’s histological resemblance to gastrointestinal tract adenocarcinoma is implied by its name. ITAC develops in the ethmoid sinus and upper nasal cavity. Herein, we present sinonasal ITAC with increased prostate-specific membrane antigen expression and fluorodeoxyglucose uptake.
Keywords:
68Ga-PSMA, sinonasal intestinal-type adenocarcinoma, fluorodeoxyglucose
Informed Consent: Patient consent was obtained.
Authorship Contributions
Surgical and Medical Practices: H.Ö., H.Öz., M.F.G., O.Ö.E., Concept: H.Ö., H.Öz., M.F.G., O.Ö.E., Design: H.Ö., H.Öz., M.F.G., O.Ö.E., Data Collection or Processing: H.Ö., H.Öz., M.F.G., O.Ö.E., Analysis or Interpretation: H.Ö., H.Öz., M.F.G., O.Ö.E., Literature Search: H.Ö., H.Öz., M.F.G., O.Ö.E., Writing: H.Ö., H.Öz., M.F.G., O.Ö.E.
Conflict of Interest: No conflicts of interest were declared by the authors.
Financial Disclosure: The authors declare that this study has received no financial support.
References
1
Kılıç S, Samarrai R, Kılıç SS, Mikhael M, Baredes S, Eloy JA. Incidence and survival of sinonasal adenocarcinoma by site and histologic subtype. Acta Otolaryngol. 2018;138:415-421.
2
Abecasis J, Viana G, Pissarra C, Pereira T, Fonseca I, Soares J. Adenocarcinomas of the nasal cavity and paranasal sinuses: a clinicopathological and immunohistochemical study of 14 cases. Histopathology. 2004;45:254-259.
3
Hoeben A, van de Winkel L, Hoebers F, Kross K, Driessen C, Slootweg P, Tjan-Heijnen VC, van Herpen C. Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment. Head Neck. 2016;38:1564-1570.
4
Choussy O, Ferron C, Védrine PO, Toussaint B, Liétin B, Marandas P, Babin E, De Raucourt D, Reyt E, Cosmidis A, Makeiff M, Dehesdin D; GETTEC Study Group. Adenocarcinoma of Ethmoid: a GETTEC retrospective multicenter study of 418 cases. Laryngoscope. 2008;118:437-443.
5
Vivanco B, Llorente JL, Perez-Escuredo J, Alvarez Marcos C, Fresno MF, Hermsen MA. Benign lesions in mucosa adjacent to intestinal-type sinonasal adenocarcinoma. Patholog Res Int. Patholog Res Int. 2011;2011:230147.
6
Projetti F, Durand K, Chaunavel A, Léobon S, Lacorre S, Caire F, Bessède JP, Moreau JJ, Coulibaly B, Labrousse F. Epidermal growth factor receptor expression and KRAS and BRAF mutations: study of 39 sinonasal intestinal-type adenocarcinomas. Hum Pathol. 2013;44:2116-2125.
7
Fu Z, Zhang J, Liu M, Li Z, Li Q. Diagnosis of Primary Intestinal-Type Adenocarcinoma in the Nasal Cavity by 18F-FDG PET/CT. Clin Nucl Med. 2016;41:888-889.
8
Backhaus P, Noto B, Avramovic N, Grubert LS, Huss S, Bögemann M, Stegger L, Weckesser M, Schäfers M, Rahbar K. Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives. Eur J Nucl Med Mol Imaging. 2018;45:860-877.
9
An S, Huang G, Liu J, Wei W. PSMA-targeted theranostics of solid tumors: applications beyond prostate cancers. Eur J Nucl Med Mol Imaging. 2022;49:3973-3976.