<sup>68</sup>Ga Prostate-specific Membrane Antigen Uptake in Metastatic Medullary Thyroid Carcinoma
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P: 54-56
February 2024

68Ga Prostate-specific Membrane Antigen Uptake in Metastatic Medullary Thyroid Carcinoma

Mol Imaging Radionucl Ther 2024;33(1):54-56
1. İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Türkiye
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Received Date: 03.07.2023
Accepted Date: 25.09.2023
Publish Date: 23.02.2024


We present the case of a 58-year-old man with advanced medullary thyroid carcinoma who had a treatment history with different types of modalities. In the follow-up, the patient had rising calcitonin and CEA levels. Metastatic lymph nodes, liver, and bone metastases with varying degrees of uptake were detected on 18F-fluorodeoxyglucose (FDG) and 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT). 68Ga prostate-specific membrane antigen (PSMA) PET/CT was performed to explore whether the patient might have a chance for PSMA-targeted radionuclide therapy, and increased PSMA expression was noted in most of the metastatic lesions, even some of which have higher PSMA uptake than 18F-FDG and 68Ga-DOTATATE.

Keywords: Medullary thyroid carcinoma, prostate-specific membrane antigen, PSMA, 18F-FDG, 68Ga-DOTA, 68Ga-PSMA


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