Abstract
Herein, we describe a rare case of multicentric Castleman disease with multiple lymph node and skin involvement. Ultrasonography of a 38-year-old patient with weakness and fever revealed multiple lymphadenopathies in both inguinal regions. Diagnosed via lymph node biopsy was Castleman’s disease, a plasma cell variant. He was diagnosed with prurigo nodularis, lymphocytic vasculitis, and stasis dermatitis in the biopsies of skin lesions located in different regions. 18F-fluorodeoxyglucose positron emission tomography/computed tomography showed multiple hypermetabolic lymph nodes in the axilla, abdomen, pelvis, and both popliteal areas, multiple hypermetabolic skin thickenings, and skin lesions in both arms, legs, and feet.
Keywords:
18F-FDG PET/CT, multicentric Castleman disease, skin involvement
Ethics
Informed Consent: Patient consent was obtained.
Authorship Contributions
Surgical and Medical Practices: M.Y., T.Ş., Concept: T.Ş., Design: M.Y., T.Ş., N.Ş.T., Data Collection or Processing: N.Ş.T., Analysis or Interpretation: T.Ş., Literature Search: M.Y., Writing: M.Y.
Conflict of Interest: No conflicts of interest were declared by the authors.
Financial Disclosure: The authors declare that this study has received no financial support.
References
1
Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956;9:822-830.
2
Cervantes CE, Correa R. Castleman disease: a rare condition with endocrine manifestations. Cureus. 2015;7:e380.
3
Kessler E. Multicentric giant lymph node hyperplasia. A report of seven cases. Cancer. 1985;56:2446-2451.
4
Uthup S, Balachandran K, Ammal VA, Abdul Salam R, George J, Nair GM, Leela M. Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma. Am J Kidney Dis. 2006;48:e17-24.
5
Kim HJ, Han JH, Bang CH, Park KS, Cho SG, Yoo DS, Kim KM, Park HJ, Park YM, Lee JY, Lee JH. Cutaneous disorders associated with Castleman’s disease. Acta Derm Venereol. 2019;99:984-989.
6
Hwang JP, Kim J, Park JM. Human immunodeficiency virus negative multicentric Castleman’s disease coexistent with Kaposi’s sarcomaon 18F FDG PET/CT: A case report. Mol Clin Oncol 2019;10:318-320.
7
Lee ES, Paeng JC, Park CM. Metabolic characteristics of castleman disease on 18F-FDG PET in relation to clinical Implication. Clin Nucl Med 2013;38:339-342.
8
Jiang Y, Hou G, Zhu Z, Huo L, Li F, Cheng W. 18F-FDG PET/CT imaging features of patients with multicentric Castleman disease. Nucl Med Commun. 2021;42:833-838.
