E-ISSN: 2147-1959
Isolated Castrate-resistant Prostate Cancer Metastasis to Both Adrenal Glands Detected on <sup>68</sup>Ga PSMA PET/CT
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VOLUME: 32 ISSUE: 3
P: 244-246
October 2023

Isolated Castrate-resistant Prostate Cancer Metastasis to Both Adrenal Glands Detected on 68Ga PSMA PET/CT

Mol Imaging Radionucl Ther 2023;32(3):244-246
DOI: 10.4274/mirt.galenos.2023.03780
Osman Kanatsız 1
Filiz Özülker 1
Tamer Aydın 2
Tamer Özülker 1
1. University of Health Sciences Türkiye, İstanbul Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Nuclear Medicine, İstanbul, Türkiye
2. University of Health Sciences Türkiye, İstanbul Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Pathology, İstanbul, Türkiye
No information available.
No information available
Received Date: 01.05.2022
Accepted Date: 15.02.2023
Publish Date: 20.10.2023
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ABSTRACT

A 61-year-old male patient, who had undergone radical prostatectomy, underwent 68Ga labeled prostate-specific membrane antigen (PSMA) positron emission tomography/computerized tomography (PET/CT) for evaluation of suspected biochemical recurrence of prostate cancer (PCa). PET/CT scan showed increased 68Ga PSMA expressions in hypodense mass lesions in both adrenal gland localizations. An adrenal gland tru-cut biopsy was performed for the right side, which showed poor-differentiated carcinoma metastases associated with the patient’s high-grade PCa. As far as we could determine based on an extensive literature search, this is the second case in which isolated adrenal metastasis was detected by 68Ga PSMA PET/CT study in a patient with PCa.

References

1
Bubendorf L, Schöpfer A, Wagner U, Sauter G, Moch H, Willi N, Gasser TC, Mihatsch MJ. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 2000;31:578-583.
2
Vinjamoori AH, Jagannathan JP, Shinagare AB, Taplin ME, Oh WK, Van den Abbeele AD, Ramaiya NH. Atypical metastases from prostate cancer: 10-year experience at a single institution. AJR Am J Roentgenol 2012;199:367-72.
3
Gandaglia G, Abdollah F, Schiffmann J, Trudeau V, Shariat SF, Kim SP, Perrotte P, Montorsi F, Briganti A, Trinh QD, Karakiewicz PI, Sun M. Distribution of metastatic sites in patients with prostate cancer: A population-based analysis. Prostate 2014;74:210-216.
4
Ashrafi AN, Fay C, Yip W, de Freitas DM, Nabhani J, Aron M. Durable biochemical response following adrenal metastasectomy for oligometastatic castrate-resistant prostate cancer. Urol Case Rep 2020;32:101229.
5
Strele-Trieb P, Dunzinger A, Sonnberger M, Wolfsgruber J, Pichler R. Uptake of 68Ga-Prostate-Specific Membrane Antigen PET in Adrenal Gland: A Potential Pitfall. Clin Nucl Med 2018;43:50-51.
6
Demirci E, Sahin OE, Ocak M, Akovali B, Nematyazar J, Kabasakal L. Normal distribution pattern and physiological variants of 68Ga-PSMA-11 PET/CT imaging. Nucl Med Commun 2016;37:1169-1179.
7
Law WP, Fiumara F, Fong W, Miles KA. Gallium-68 PSMA uptake in adrenal adenoma. J Med Imaging Radiat Oncol 2016;60:514-517.
8
Crowley MJ, Scognamiglio T, Liu YF, Kleiman DA, Beninato T, Aronova A, Liu H, Jhanwar YS, Molina A, Tagawa ST, Bander NH, Zarnegar R, Elemento O, Fahey TJ 3rd. Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma. J Clin Endocrinol Metab 2016;101:981-987.
9
Arora S, Damle NA, Aggarwal S, Passah A, Behera A, Arora G, Bal C, Tripathi M. Prostate-Specific Membrane Antigen Expression in Adrenocortical Carcinoma on 68Ga-Prostate-Specific Membrane Antigen PET/CT. Clin Nucl Med 2018;43:449-451.
10
Ribeiro AMB, Lima ENP, Garcia D, Bezerra SM. Single Adrenal Metastasis From Prostate Cancer Detected by 68Ga-PSMA PET/CT and Confirmed by Biopsy: A Case Report. Clin Nucl Med 2022;47:61-62.