ABSTRACT
Breast metastasis of the well differentiated neuroendocrin tumor (WDNET) of the ileum is very rare. A case of a 62-year-old woman with ileal WDNET, who underwent restaging with Ga-68 DOTATATE PET/CT due to progression of metastatic lesions under the treatment with somatostatin analog and mammalian target of rapamycin inhibitors. Ga-68 DOTATATE PET/CT demonstrated intense increased uptake in the subsantimetric nodular lesion in the upper outer quadrant of the left breast. The histopathologic findings obtained by tru-cut biopsy revealed WDNET metastasis (Ki-67 proliferation index 1%).
References
1Subramaniam RM, Bradshaw LM, Lewis K, Pinho D, Shah C, Walker RC. ACR Practice parameter for the performance of Gallium-68 DOTATATE PET/CT for neuroendocrin tumors. Clin Nucl Med 2018;43:899-908.
2Modlin IM, Lye KD, Kidd M. A 5 decade analysis of 13,715 carcinoid tumors. Cancer 2003;15:934-959.
3Clark BZ, Bhargava R. Metastatic neuoroendocrin tumors to the breast: Diagnostic pitfall with significant clinical implications. AJSP 2017;22:269-274.
4Dervishac OA, Renzi AS, Genato R, Xiao PQ, Asarian AP. Neuroendocrin tumor of the breast:is it primary or metastatic? Int J Case Rep Images 2016;7:34-39.
5Ahn S, Bhagwandin S, Reindl B, Jaffer S, Bickell N, Labow DM, Scmidt H. Metastatic carcinoid tumor presenting as a breast mass: A case report and review of the literature. Arch Surg Oncol 2016;2:1-5.
6Policeni F, Pakalniskis B, Yang L. Occult primary neuroendocrin tumor metastasis to breast detected on screeniig mammogram. J Clin Imaging Sci 2016;6:41.
