E-ISSN: 2147-1959
Detection of Squamous Cell Carcinoma Foci in a Patient with Dystrophic Epidermolysis Bullosa in 18F-FDG PET/CT
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VOLUME: 28 ISSUE: 2
P: 79 - 82
June 2019

Detection of Squamous Cell Carcinoma Foci in a Patient with Dystrophic Epidermolysis Bullosa in 18F-FDG PET/CT

Mol Imaging Radionucl Ther 2019;28(2):79-82
Esra Arslan 1
Tevfik Fikret Çermik 1
Ayşe Esra Koku Aksu 2
Mehmet Salih Gürel 2
Cem Leblebici 3
1. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey
2. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Dermatology, İstanbul, Turkey
3. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Pathology, İstanbul, Turkey
No information available.
No information available
Received Date: 21.07.2018
Accepted Date: 12.11.2018
Publish Date: 24.06.2019
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ABSTRACT

Dystrophic epidermolysis bullosa (DEB) is a rare, inherited skin fragility disorder characterized by blister formation in the sublamina densa. DEB is associated with aggressive squamous cell carcinoma (SCC) that has increased risk of metastases and poor prognosis. A 41-year-old woman with DEB underwent 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/BT). PET/CT showed increased 18F-FDG uptakes in multifocal cutaneous lesions in both lower extremities. The patient was diagnosed with SCC via skin biopsy from the left lateral lower thigh. Ten months later, PET/CT showed increased FDG uptakes in the primary tumor area as well as the left inguinal and left supraclavicular lymph node regions. 18F-FDG PET/CT seems to be useful for re-staging and planning appropriate therapeutic strategy in DEB-patients with SCC.

Keywords:
18F-FDG PET/CT, dystrophic epidermolysis bullosa, squamous cell carcinoma

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