E-ISSN: 2147-1959
Detection of Squamous Cell Carcinoma Foci in a Patient with Dystrophic Epidermolysis Bullosa in <sup>18</sup>F-FDG PET/CT
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VOLUME: 28 ISSUE: 2
P: 79-82
June 2019

Detection of Squamous Cell Carcinoma Foci in a Patient with Dystrophic Epidermolysis Bullosa in 18F-FDG PET/CT

Mol Imaging Radionucl Ther 2019;28(2):79-82
DOI: 10.4274/mirt.galenos.2018.96658
Esra Arslan 1
Tevfik Fikret Çermik 1
Ayşe Esra Koku Aksu 2
Mehmet Salih Gürel 2
Cem Leblebici 3
1. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey
2. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Dermatology, İstanbul, Turkey
3. University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Pathology, İstanbul, Turkey
No information available.
No information available
Received Date: 21.07.2018
Accepted Date: 12.11.2018
Publish Date: 24.06.2019
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ABSTRACT

Dystrophic epidermolysis bullosa (DEB) is a rare, inherited skin fragility disorder characterized by blister formation in the sublamina densa. DEB is associated with aggressive squamous cell carcinoma (SCC) that has increased risk of metastases and poor prognosis. A 41-year-old woman with DEB underwent 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/BT). PET/CT showed increased 18F-FDG uptakes in multifocal cutaneous lesions in both lower extremities. The patient was diagnosed with SCC via skin biopsy from the left lateral lower thigh. Ten months later, PET/CT showed increased FDG uptakes in the primary tumor area as well as the left inguinal and left supraclavicular lymph node regions. 18F-FDG PET/CT seems to be useful for re-staging and planning appropriate therapeutic strategy in DEB-patients with SCC.

References

1Schwieger-Briel A, Kiritsi D, Schempp C, Has C, Schumann H. Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study. Dermatol Res Pract 2017;2017:5068969.
2Fine JD, Bruckner-Tuderman L, Eady RA, Bauer EA, Bauer JW, Has C, Heagerty A, Hintner H, Hovnanian A, Jonkman MF, Leigh I, Marinkovich MP, Martinez AE, McGrath JA, Mellerio JE, Moss C, Murrell DF, Shimizu H, Uitto J, Woodley D, Zambruno G. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification. J Am Acad Dermatol 2014;70:1103-1126.
3Montaudie H, Chiaverini C, Sbidian E, Charlesworth A, Lacour JP. Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases. Orphanet J Rare Dis 2016;11:117.
4Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Becker JC, Zalaudek I, Saiag P, Middleton MR, Bastholt L, Testori A, Grob JJ; European Dermatology Forum (EDF); European Association of Dermato-Oncology (EADO); European Organization for Research and Treatment of Cancer (EORTC). Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer 2015;51:1989-2007.
5Jennings L, Schmults CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol 2010;3:39-48.
6Cho SB, Chung WG, Yun M, Lee JD, Lee MG, Chung KY. Fluorodeoxyglucose positron emission tomography in cutaneous squamous cell carcinoma: retrospective analysis of 12 patients. Dermatol Surg 2005;31:446-447.
7Mahajan S, Barker CA, Singh B, Pandit-Taskar N. Clinical value of 18F-FDG-PET/CT in staging cutaneous squamous cell carcinoma. Nucl Med Commun 2019.
8Mackie GC, Avram AM. FDG PET imaging features of epidermolysis bullosa complicated by squamous cell carcinoma. Clin Nucl Med 2005;30:69-71.
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