ABSTRACT
A 76-year-old male, previously submitted enucleation renal-cell carcinoma (pT1) and prostatectomy for prostate cancer (Gleason score 3+5, pT3b pN0 pMx), was submitted to positron emission/computed tomography (PET/CT) with 18F-choline for restaging due to raised levels of prostate-specific antigen. PET/CT scan showed increased tracer incorporation corresponding to bone metastases in the left ischio-pubic ramus, also revealing 2 areas of increased tracer uptake in the cerebellum, subsequently confirmed by brain magnetic resonance imaging. The patient was urgently submitted to neurosurgery. Post-operative histology was positive for brain metastases from prostate cancer.
References
1
Estebanez J, Teyrouz A, Gutierrez MA, Linazasoro I, Belloso J, Cano C, Peralta JM, Sanz JP. Natural history of prostate cancer. Arch Esp Urol 2014;67:383-387.
2
Macedo J, Carneiro E, Ferreira D, Verdelho A, Afonso LP, MaurĂcio J, Silva SM, Arantes M. Neuroimaging analysis of rare brain metastases from prostate cancer: PS171. Porto Biomed J 2017;2:220.
3
Filippi L, Basile P, Schillaci O, Bagni O. The Relationship between total lesion activity on 18F choline positron emission tomography-computed tomography and clinical outcome in patients with castration-resistant prostate cancer bone metastases treated with 223Radium. Cancer Biother Radiopharm 2020;35:398-403.
4
Treglia G, Muoio B, Trevisi G, Mattoli MV, Albano D, Bertagna F, Giovanella L. Diagnostic performance and prognostic value of PET/CT with different tracers for brain tumors: a systematic review of published meta-analyses. Int J Mol Sci 2019;20:4669.
5
Gizewska A, Witkowska-Patena E, Stembrowicz-Nowakowska Z, Buraczewska A, Dziuk M. Brain metastases in patient with prostate cancer found in 18F-choline PET/CT. Nucl Med Rev Cent East Eur 2015;18:39-41.