Bone Marrow Necrosis with Underlying Skeletal Lymphoma Evaluated by <sup>18</sup>F-FDG PET/CT and MRI
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Bone Marrow Necrosis with Underlying Skeletal Lymphoma Evaluated by 18F-FDG PET/CT and MRI

Mol Imaging Radionucl Ther 0;0(0):undefined-undefined
1. Peking University Third Hospital Departments of Nuclear Medicine, Beijing, China
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Abstract

Bone marrow necrosis (BMN) is usually associated with malignancies and is characterized by multiple geographic signal abnormalities on magnetic resonance imaging (MRI). We report a 28-year-old female with BMN and underlying diffuse large B-cell lymphoma. Diffuse abnormal signal intensities through the vertebral column were demonstrated on her pretreatment MRI, and the diagnosis of BMN was challenging. Positron emission tomography/computed tomography (PET/CT) for lymphoma staging showed multiple decreased or absent 18F-fluorodeoxyglucose (18F-FDG) uptake within the vertebrae and pelvis. Marrow biopsy pathological examination showed lymphoma infiltration and massive necrosis. On the follow-up MRI obtained approximately 21 months after the PET/CT scan, multiple geographic abnormal signal intensities were detected within the vertebral column and were consistent with the areas of decreased 18F-FDG uptake on PET/CT. This case indicates that 18F-FDG PET/CT is helpful in the diagnosis of BMN with atypical MRI appearances.

Keywords: Bone marrow necrosis, lymphoma, 18F-FDG PET/CT, MRI

References

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