Atypical Presentation of Metastatic Castrate-resistant Prostate Cancer in a Middle Aged African Male with Good Response to Radioligand Therapy
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P: 57-62
February 2024

Atypical Presentation of Metastatic Castrate-resistant Prostate Cancer in a Middle Aged African Male with Good Response to Radioligand Therapy

Mol Imaging Radionucl Ther 2024;33(1):57-62
1. University of The Free State, Department of Nuclear Medicine, Bloemfontein, South Africa
No information available.
No information available
Received Date: 12.04.2023
Accepted Date: 15.10.2023
Publish Date: 23.02.2024


Prostate cancer typically follows a characteristic pattern of metastatic spread to the pelvic lymph nodes and bone. Atypical patterns of metastasis are rare but have been documented. In African men, this disease tends to follow a more aggressive course, with the possibility of an atypical site of metastatic spread. We present a case of a 58-year- old African male with metastatic castrate-resistant prostate cancer who presented with both typical and atypical patterns of metastatic disease detected by a fluorine 18 prostate-specific membrane antigen positron emission tomography/computed tomography scan. This patient also had a good response to radioligand therapy.

Keywords: Metastatic castrate-resistant prostate cancer, atypical metastases, 18F-PSMA


Ss M, Masood N. Prostatic Adenocarcinoma - A Case with adrenal gland and bone metastasis. iMedPub Journals 2018;1-2.
Vinjamoori AH, Jagannathan JP, Shinagare AB, Taplin ME, Oh WK, Van den Abbeele AD, Ramaiya NH. Atypical metastases from prostate cancer: 10-year experience at a single institution. AJR Am J Roentgenol 2012;199:367-372.
Gandaglia G, Abdollah F, Schiffmann J, Trudeau V, Shariat SF, Kim SP, Perrotte P, Montorsi F, Briganti A, Trinh QD, Karakiewicz PI, Sun M. Distribution of metastatic sites in patients with prostate cancer: A population-based analysis. Prostate 2014;74:210-216.
Kurtul N, Resim S, Koçarslan S. Giant renal metastasis from prostate cancer mimicking renal cell carcinoma. Turk J Urol 2018;44:367-369.
Khan F, Mahmalji W, Sriprasad S, Madaan S. Prostate cancer with metastases to the kidney: a rare manifestation of a common disease. BMJ Case Rep 2013;2013:bcr2012008388.
Chen C, He H, Yu Z, Qiu Y, Wang X. Renal and retroperitoneal metastasis from prostate adenocarcinoma: a case report. World J Surg Oncol 2016;14:74.
Gergelis KR, Remme DS, Choo CR. Isolated biopsy-proven recurrence of prostate carcinoma in the spermatic cord after radical prostatectomy detected with 11C-Choline PET/CT. Urol Case Rep 2019;26:100985.
Kasai Y, Sawada N, Yamagishi T, Kamiyama M, Mitsui T, Takeda M. A case of urethral metastasis of castration-resistant prostate cancer successfully cured with CyberKnife radiosurgery. Urol Case Rep 2020;33:101346.
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