Alterations in <sup>18</sup>F-FDG Uptake Patterns may Limit Cross-sectional Evaluation of Adrenal Adenomas Using Single <sup>18</sup>F-FDG PET/CT Imaging
PDF
Cite
Share
Request
Interesting Image
P: 247-249
October 2023

Alterations in 18F-FDG Uptake Patterns may Limit Cross-sectional Evaluation of Adrenal Adenomas Using Single 18F-FDG PET/CT Imaging

Mol Imaging Radionucl Ther 2023;32(3):247-249
1. Niğde Ömer Halisdemir University Training and Research Hospital, Clinic of Nuclear Medicine, Niğde, Türkiye
2. Ege University Faculty of Medicine, Department of Nuclear Medicine, İzmir, Türkiye
No information available.
No information available
Received Date: 11.01.2023
Accepted Date: 01.03.2023
Publish Date: 20.10.2023
PDF
Cite
Share
Request

ABSTRACT

Adrenal adenomas are observed in up to 7% of the population and are predominantly non-functional, increased 18F-fluorodeoxyglucose (FDG) uptake is seen in only a small portion of them on 18F-FDG positron emission tomography/computed tomography (PET/CT) imaging. In this report, we present the sequential 18F-FDG PET/CT imaging findings of 2 patients with radiologically or pathologically confirmed adrenal adenomas who had severely altered 18F-FDG uptake patterns in adrenal lesions in different imaging studies of the same patient. In light of these findings, we wanted to highlight that evaluating adrenal adenomas as cross-sectional with semi-quantitative PET/CT parameters obtained from single imaging may cause misinterpretation.

References

1Chong S, Lee KS, Kim HY, Kim YK, Kim BT, Chung MJ, Yi CA, Kwon GY. Integrated PET-CT for the characterization of adrenal gland lesions in cancer patients: diagnostic efficacy and interpretation pitfalls. Radiographics 2006;26:1811-1824.
2Ansquer C, Scigliano S, Mirallié E, Taïeb D, Brunaud L, Sebag F, Leux C, Drui D, Dupas B, Renaudin K, Kraeber-Bodéré F. 18F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation. Eur J Nucl Med Mol Imaging 2010;37:1669-1678.
3Boland GW, Dwamena BA, Jagtiani Sangwaiya M, Goehler AG, Blake MA, Hahn PF, Scott JA, Kalra MK. Characterization of adrenal masses by using FDG PET: a systematic review and meta-analysis of diagnostic test performance. Radiology 2011;259:117-126.
4Kim SJ, Lee SW, Pak K, Kim IJ, Kim K. Diagnostic accuracy of 18F-FDG PET or PET/CT for the characterization of adrenal masses: a systematic review and meta-analysis. Br J Radiol 2018;91:20170520.
5He X, Caoili EM, Avram AM, Miller BS, Else T. 18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients. J Clin Endocrinol Metab 2021;106:1448-1459.
6Takanami K, Kaneta T, Morimoto R, Satoh F, Nakamura Y, Takase K, Takahashi S. Characterization of lipid-rich adrenal tumors by FDG PET/CT: Are they hormone-secreting or not? Ann Nucl Med 2014;28:145-153.
7Lang BH, Cowling BJ, Li JY, Wong KP, Wan KY. High False Positivity in Positron Emission Tomography is a Potential Diagnostic Pitfall in Patients with Suspected Adrenal Metastasis. World J Surg 2015;39:1902-1908.
8Murayama R, Nishie A, Hida T, Baba S, Inokuchi J, Oda Y, Honda H. Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells. Clin Nucl Med 2019;44:943-948.
Article is only available in PDF format. Show PDF
2024 ©️ Galenos Publishing House