E-ISSN: 2147-1959
Almost Complete Response with a Single Administration <sup>225</sup>Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary
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VOLUME: 31 ISSUE: 2
P: 139-141
June 2022

Almost Complete Response with a Single Administration 225Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary

Mol Imaging Radionucl Ther 2022;31(2):139-141
DOI: 10.4274/mirt.galenos.2022.64497
Nalan Alan Selçuk 1
Emre Demirci 1
Meltem Ocak 2
Türkay Toklu 1
Selçuk Ergen 3
Levent Kabasakal 4
1. Yeditepe University Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Turkey
2. İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Turkey
3. Yeditepe University Faculty of Medicine, Department of Medical Oncology, İstanbul, Turkey
4. İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Turkey
No information available.
No information available
Received Date: 30.07.2021
Accepted Date: 07.01.2022
Publish Date: 28.06.2022
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ABSTRACT

Neuroendocrine tumors (NETs) are being seen increasingly frequently, and the only known curative treatment method is surgical resection. Peptide receptor radionuclide therapy (PRRT) is a treatment option that the most contributes to progression-free survival and overall survival in metastatic cases.β-emitting radionuclides are traditionally used for PRRT. Nowadays, alpha particle-emitting radionuclides are being developed, with advantages in terms of very high energy and a short path length, which should theoretically show higher efficacy. In this case; in a patient with NET diagnosis who had multiple (>50) lesions in the abdomen, almost all the lesions disappeared with a single dose application. This paper aims to present a case in which we observed the efficacy of 225Ac-DOTATATE treatment, which is an alpha treatment.

Keywords:
225Ac targeted alpha therapy, neuroendocrine tumors, peptide receptor radionuclide therapy

References

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