ABSTRACT
Glioblastoma multiforme (GBM) is the most common primary malignant tumor of the central nervous system in adults. It is known for its devastating intracranial progress thus attributing to its very short survival. Here, we report a case of 37-year-old female with GBM post surgery, chemotherapy and radiotherapy who presented with pain in right hip region. She was referred to our department for evaluation of skeletal metastasis. Tc-99m methylene diphosphonate bone scan revealed an expansile lesion involving the right iliac blade along with extensive lytic bony lesions throughout the axial skeleton.
References
1
Simonetti G, Silvani A, Fariselli L, Hottinger AF, Pesce GA, Prada F, Gaviani P. Extra central nervous system metastases from glioblastoma: a new possible trigger event? Neurol Sci 2017;38:1873-1875.
2
Seo YJ, Cho WH, Kang DW, Cha SH. Extraneural metastasis of glioblastoma multiforme presenting as an unusual neck mass. J Korean Neurosurg Soc 2012;51:147-150.
3
Ricard JA, Cramer SW, Charles R, Tommee CG, Le A, Bell WR, Chen CC, Flanagan E. Infratentorial glioblastoma metastasis to bone. World Neurosurg 2019;131:90-94.
4
Rossi J, Giaccherini L, Cavallieri F, Napoli M, Moratti C, Froio E, Serra S, Fraternali A, Ghadirpour R, Cozzi S, Ciammella P, Iaccarino C, Pascarella R, Valzania F, Pisanello A. Extracranial metastases in secondary glioblastoma multiforme: a case report. BMC Neurol 2020;20:382.
5
Sibanda Z, Farahani N, Ogbonnaya E, Albanese E. Glioblastoma multiforme: a rare case of spinal drop metastasis. World Neurosurg 2020;144:24-27.
6
Undabeitia J, Castle M, Arrazola M, Pendleton C, Ruiz I, Úrculo E. Multiple extraneural metastasis of glioblastoma multiforme. An Sist Sanit Navar 2015;38:157-161.
7
Shastin D, Mathew RK, Ismail A, Towns G. Cervical spinal glioblastoma multiforme in the elderly. BMJ Case Rep 2017;2017:bcr2016217742.
8
Forsyth TM, Bi WL, Abedalthagafi M, Dunn IF, Chiocca EA. Extracranial growth of glioblastoma multiforme. J Clin Neurosci 2015;22:1521-1523.
9
Rosen J, Blau T, Grau SJ, Barbe MT, Fink GR, Galldiks N. Extracranial metastases of a cerebral glioblastoma: a case report and review of the literature. Case Rep Oncol 2018;11:591-600.
10
Pietschmann S, von Bueren AO, Kerber MJ, Baumert BG, Kortmann RD, Müller K. An individual patient data meta-analysis on characteristics, treatments and outcomes of glioblastoma/ gliosarcoma patients with metastases outside of the central nervous system. PLoS One 2015;10:e0121592.
11
Beauchesne P. Extra-neural metastases of malignant gliomas: myth or reality? Cancers (Basel) 2011;3:461-477.