Interesting Image

Unusual Uptake of [131I] in a Tenosynovial Giant Cell Tumour Relapse in a Patient with Differentiated Thyroid Cancer


  • Francisco Manuel Cañete Sánchez
  • Leonardo Gabriel Romero Robles
  • Xavier Louis Boulvard Chollet
  • María Mangas Losada
  • Puy Garrastachu
  • Antonio Cabrera Villegas
  • Rafael Ramírez Lasanta
  • Roberto Delgado Bolton

Received Date: 16.10.2020 Accepted Date: 01.04.2021 Mol Imaging Radionucl Ther 2022;31(2):145-147 PMID: 35771035

A 77-year-old woman with follicular thyroid cancer underwent total thyroidectomy and subsequent Iodine-131 remnant ablation. She had a history of a wide tenosynovial giant cell tumor (TGCT) of the right wrist and hand that had been resected thirteen years ago. Post-therapeutic scintigraphy and single photon emission computed tomography showed mild uptake on the distal right forearm, wrist and hand. Magnetic resonance imaging and posterior histopathology confirmed a relapse of TGCT. No radioiodine adverse effects were reported after a one-year follow-up. As far as we know, this report is the first in the literature to a TGCT visualized on post-therapy radioiodine scan.

Keywords: Giant cell tumor of tendon sheath, thyroid neoplasms, scintigraphy, magnetic resonance imaging


Informed Consent: Consent form was filled out by the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Concept: F.M.C.S., L.G.R.R., R.D.B., Design: F.M.C.S., L.G.R.R., X.L.B.C., R.D.B., Data Collection or Processing: F.M.C.S., L.G.R.R., R.D.B., Literature Search: F.M.C.S., L.G.R.R., X.L.B.C., R.D.B., Writing: F.M.C.S., L.G.R.R., X.L.B.C., M.M.L., P.G., A.C.V., R.R.L., R.D.B.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


  1. Gouin F, Noailles T. Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res 2017;103:S91-S97.
  2. Mastboom MJL, Verspoor FGM, Hanff DF, Gademan MGJ, Dijkstra PDS, Schreuder HWB, Bloem JL, van der Wal RJP, van de Sande MAJ. Severity classification of tenosynovial giant cell tumours on MR imaging. Surg Oncol 2018;27:544-550.
  3. Jain JK, Vidyasagar JV, Sagar R, Patel H, Chetan ML, Bajaj A. Arthroscopic synovectomy in pigmented villonodular synovitis of the knee: clinical series and outcome. Int Orthop 2013;37:2363-2369.
  4. Mastboom MJL, Palmerini E, Verspoor FGM, Rueten-Budde AJ, Stacchiotti S, Staals EL, Schaap GR, Jutte PC, Aston W, Gelderblom H, Leithner A, Dammerer D, Takeuchi A, Thio Q, Niu X, Wunder JS; TGCT Study Group, van de Sande MAJ. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study. Lancet Oncol 2019;20:877-886.
  5. Liu Z, Xing M. Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells. PLoS One 2012;7:e31729.
  6. Oh JR, Ahn BC. False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am J Nucl Med Mol Imaging 2012;2:362-385.
  7. Anh BC. Physiologic and false positive pathologic uptakes on radioiodine whole body scan. 12 Chapters on Nuclear Medicine. InTech; 2011.
  8. Bassetti E, Candreva R, Santucci E. Giant cell tumor of the flexor tendon of the wrist: US and MRI evaluation. Case report. J Ultrasound 2011;14:37-39.