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Unexpected Metastatic Localizations of Prostate Cancer Determined by 68Ga PSMA PET/CT: Series of Four Cases


  • Gözde Mütevelizade
  • Ceren Sezgin
  • Gül Gümüşer
  • Elvan Sayit

Received Date: 02.04.2021 Accepted Date: 16.06.2021 Mol Imaging Radionucl Ther 2022;31(3):223-226 PMID: 36268896

Prostate-specific membrane antigen (PSMA) is a transmembrane protein with overexpression in most prostate cancer cells. Gallium-68-(68Ga) PSMA positron emission tomography/computed tomography (PET/CT) imaging is a game-changer in the management of prostate cancer. 68Ga PSMA PET/CT scan is advanced and a promising radioligand has high sensitivity in determining lesions of prostate cancer with a high tumor to background ratio. The most common areas of metastasis are the bone and pelvic lymph nodes. The prognosis of prostate cancer is mainly determined by the status of metastases. The presence and the localization of metastases affects treatment planning. In our cases, we presented some examples of uncommon sites of metastases such as the brain, adrenal glands, penis and orbit. Improvements in imaging techniques, such as 68Ga PSMA PET/CT have led to the possibility to make more determi nation of rare metastase sites in prostate cancer patients.

Keywords: Prostate cancer, unexpected, metastases, 68Ga PSMA PET/CT


Informed Consent: Written informed consent was obtained from the patients who participated in this study.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: G.M., C.S., Concept: G.M., E.S., Design: G.M., G.G., Data Collection or Processing: G.M., C.S., Analysis or Interpretation: G.M., G.G., Literature Search: G.M., E.S., Writing: G.M.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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