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Two Rare Benign Lesions on 18F-FDG PET/CT: Peliosis Hepatis and SANT


  • Ediz Beyhan
  • Ahu Senem Demiröz
  • İbrahim Taşkın Rakıcı
  • Tevfik Fikret Çermik
  • Esra Arslan

Received Date: 21.03.2023 Accepted Date: 29.05.2023 Mol Imaging Radionucl Ther 2024;33(1):43-46 PMID: 38390788

Peliosis hepatis (PH) and sclerosing angiomatoid nodular transformation of the spleen are uncommon benign lesions. Diagnosis can be difficult in some patients. Herein, we present the case of a 28-year-old woman referred with abdominal pain who had spleen lesions. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography revealed multiple non-FDG avid lesions in the liver and hypermetabolic lesions in the spleen. In addition, abdominal magnetic resonance imaging was performed. Histopathology revealed sclerosing angiomatoid nodular transformation in the spleen and PH in the liver.

Keywords: Peliosis hepatis, splenic lesions, liver lesions, 18F-FDG PET/CT, SANT


Informed Consent: Patient consent was obtained.

Authorship Contributions

Surgical and Medical Practices: A.S.D., E.B., İ.T.R., T.F.Ç, E.A., Concept: E.A., T.F.Ç, E.B., A.S.D., İ.T.R., Design: T.F.Ç, E.A., E.B., A.S.D., İ.T.R., Data Collection or Processing: İ.T.R., E.B., A.S.D., T.F.Ç, E.A., Analysis or Interpretation: E.A., T.F.Ç, E.B., A.S.D., İ.T.R., Literature Search: E.B., E.A., A.S.D., İ.T.R., T.F.Ç, Writing: E.B., E.A., A.S.D., İ.T.R., T.F.Ç.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support.


  1. Sangiorgio VFI, Arber DA. Non-hematopoietic neoplastic and pseudoneoplastic lesions of the spleen. Semin Diagn Pathol 2021;38:159-164.
  2. Zhang ZB, Li L. Splenic sclerosing angiomatoid nodular transformation in a patient with right renal carcinoma: A case report. Asian J Surg 2021;44:396-397.
  3. Feng YM, Huang YC, Tu CW, Kao WS, Tu DG. Distinctive PET/CT features of splenic SANT. Clin Nucl Med 2013;38:e465-e466.
  4. Dave YA, Gupta A, Shah MM, Carpizo D. Liver haematoma as a presentation of peliosis hepatis. BMJ Case Rep 2019;12:e226737
  5. Holmes JA, Chung RT. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ (eds). Sleisenger and Foltran’s Sleisenger and Fordtran›s Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Canada, Elsevier, 2021;1243-1283.
  6. Imamura Y, Nakajima R, Hatta K, Seshimo A, Sawada T, Abe K, Sakai S. Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a case report with FDG-PET findings and literature review. Acta Radiol Open 2016;5:2058460116649799.
  7. Seo M, Lee SH, Han S, Sung C, Son DH, Lee JJ. Peliosis hepatis shows isometabolism on (18)F-FDG PET/CT: two case reports. Nucl Med Mol Imaging 2014;48:309-312.
  8. Levin D, Hod N, Anconina R, Ezroh Kazap D, Shaco-Levy R, Lantsberg S. Peliosis hepatis simulating metastatic liver disease on FDG PET/CT. Clin Nucl Med 2018;43:e234-e236.