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The Role of a Bone SPECT/CT Scan in the Follow-up of a Solitary Bone Lesion in a Patient with Langerhans’ Cell Histiocytosis


  • Selin Kesim
  • Halil Turgut Turoğlu
  • Sabahat İnanır
  • Salih Özgüven
  • Tanju Yusuf Erdil

Received Date: 28.04.2020 Accepted Date: 29.06.2020 Mol Imaging Radionucl Ther 2021;30(3):187-189 PMID: 34659423

Langerhans’ cell histiocytosis (LCH) is a rare disease observed in childhood characterized by the proliferation of Langerhans’ cells resulting in focal or systemic manifestations (including the bones). Here, we present a pediatric case with a localized biopsy-proven LCH, who underwent progression from solitary to multifocal form detected on bone scintigraphy and single photon emission computerized tomography/computed tomography (SPECT/CT) performed within four months. Emphasizing on localized bone pain (predictive of osseous LCH) and local tenderness and swelling usually guides the nuclear physician to perform additional SPECT/CT with presumably an improvement of the diagnostic accuracy as demonstrated in our case.

Keywords: Langerhans’ cell histiocytosis, technetium-99m-methylene diphosphonate bone scintigraphy, bone SPECT/CT


Informed Consent: All appropriate patient consent forms were obtained. In the form, the patient gave consent for their pictures and other clinical information to be reported in the journal.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: S.K., H.T.T, S.İ., S.Ö., T.Y.E., Concept: S.K., H.T.T., Design: S.K., H.T.T. Data Collection or Processing: S.K., H.T.T., Analysis or Interpretation: S.K., H.T.T., Literature Search: S.K., H.T.T., Writing: S.K., H.T.T.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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