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Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with 18F-FDG PET/CT


  • Esra Arslan
  • Tamer Aksoy
  • Süheyla Ekemen
  • Tevfik Fikret Çermik

Received Date: 10.11.2019 Accepted Date: 13.06.2020 Mol Imaging Radionucl Ther 2021;30(2):126-128 PMID: 34082518

A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred for 18fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for complaints of weight loss and fever. PET/CT showed multiple and progressive 18F-FDG uptakes in supra and infra diaphragmatic lymphatic regions, and multiple abnormal 18F-FDG uptakes were noted in the lytic formed skeletal lesions. Clinicians remain in doubt regarding the multiple metastatic lesions without elevated serum tumor marker levels (alpha-fetoprotein, beta-human chorionic gonadotrophin, CA19-9, and carcinoembryonic antigen).

Biopsy of the lytic lesion in the iliac bone revealed granulomatous inflammation suggestive of sarcoidosis. Systemic prednisone at 20-40 mg/daily was started. 18F-FDG PET/CT images showed complete metabolic response to prednisone 8 months following the start of treatment.

Keywords: Systemic sarcoidosis, testis carcinoma, 18F-FDG PET/CT


Informed Consent: Was obtained from the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: S.E., Concept: E.A., T.A., S.E., T.F.Ç., Design: E.A., T.A., S.E., T.F.Ç., Data Collection or Processing: E.A., T.A., S.E., T.F.Ç., Analysis or Interpretation: E.A., T.A., S.E., T.F.Ç., Literature Search: E.A., T.A., S.E., T.F.Ç., Writing: E.A., T.A., T.F.Ç.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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