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Synchronous Hepatocellular Carcinoma and Cholangiocellular Carcinoma on 18F-FDG PET/CT


  • Ezgi Başak Erdoğan
  • Hacı Mehmet Türk
  • Ertuğrul Tekçe
  • Mehmet Aydın

Received Date: 06.11.2017 Accepted Date: 12.06.2018 Mol Imaging Radionucl Ther 2018;27(3):136-137 PMID: 30317851

A 43-year-old male patient presented with a mass lesion on the right liver lobe, segment 5, in radiological imaging and elevated alpha-fetoprotein levels (323 ng/mL) compatible with hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) images showed background level 18F-FDG uptake in the mass lesion. In addition, a secondary focus of increased 18F-FDG uptake was detected on the left liver lobe, segment 2, approximately 1,5 cm in diameter. Histopathological examination revealed HCC in the larger mass lesion with a lower 18F-FDG uptake, and cholangiocellular carcinoma in the smaller mass lesion with a higher 18F-FDG uptake. To our knowledge, this is the first case report of two histopathologically different primary malignant liver tumors in two distinct segments of the liver detected by PET/CT.

Keywords: Synchronous tumors, hepatocellular carcinoma, cholangiocellular carcinoma, 18F-FDG PET/CT


Informed Consent: Consent form was filled out by participant.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: H.M.T., Concept: E.B.E., H.M.T., E.T., M.A., Design: E.B.E., M.A., Data Collection or Processing: E.B.E., H.M.T., Analysis or Interpretation: E.B.E., M.A., Literature Search: E.B.E., Writing: E.B.E., E.T., M.A.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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