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18F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign


  • Sharjeel Usmani
  • Najeeb Ahmed

Received Date: 05.05.2020 Accepted Date: 16.07.2020 Mol Imaging Radionucl Ther 2021;30(3):190-192 PMID: 34659651

18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci. Here, we describe a case of a 48-year-old man with bladder carcinoma referred for staging using 18F-NaF positron emission tomography/computed tomography (PET/CT). 18F-NaF PET/CT detected a calcified soft tissue mass in the urinary bladder. Extraosseous 18F-NaF uptake is often encountered and these non-osseous findings could possibly provide important diagnostic information. Thus, recognition of extraosseous 18F-NaF activity has implications for accurate staging and management.

Keywords: 18F-NaF PET/CT, bladder carcinoma, extraosseous uptake, metastasis


Informed Consent: The institutional review board waived the need to obtain informed consent.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: S.U., Concept: S.U., N.A., Design: S.U., N.A., Data Collection or Processing: S.U., N.A., Analysis or Interpretation: S.U., N.A., Literature Search: S.U., Writing: S.U., N.A.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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