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Striking Visualization of Diffuse Congenital Nesidioblastosis on Ga-68 DOTATATE PET/CT


  • Fevziye Canbaz
  • Murat Aydın
  • Bilge Can Meydan
  • Meltem Ceyhan Bilgici
  • Ender Arıtürk

Received Date: 22.09.2018 Accepted Date: 04.11.2018 Mol Imaging Radionucl Ther 2019;28(2):83-85 PMID: 31237140

“Nesidioblastosis”, later renamed as “persistent hyperinsulinemic hypoglycemia of infancy” presents as either focal or diffuse neo-differentiation of pancreatic Langerhans islet cells from the ductal epithelium. Differentiation of focal disease from diffuse involvement is crucial for optimal disease management. The current methods used to differentiate the two forms pre-operatively are invasive techniques. The definite role of imaging modalities to differentiate diffuse versus focal form has not yet been proven. Herein, we report a 15 day-old infant having diffuse nesidioblastosis, successfully demonstrated by Ga-68 DOTATATE positron emission tomography/computed tomography imaging that was histopathologically confirmed.

Keywords: Nesidioblastosis, hyperinsulinemic hypoglycemia, differential diagnosis, Ga-68 DOTATATE PET/CT


Informed Consent:Consent form was filled out by all participants.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: E.A., H.M.A., Concept: F.C., Design: F.C., Data Collection or Processing: F.C., Analysis or Interpretation: F.C., B.C.M., M.C.B., Literature Search: F.C., Writing: F.C.

Conflict of Interest:No conflict of interest was declared by the authors.

Financial Disclosure:The authors declared that this study received no financial support.


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