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Oncological Follow-up with 2-[18F]-FDG PET/CT in Li-Fraumeni Syndrome


  • Marylin Acuña Hernandez
  • Iván Fabricio Vega Gonzalez
  • Lina López Vélez
  • Catalina Melo Arango

Received Date: 10.11.2019 Accepted Date: 24.04.2020 Mol Imaging Radionucl Ther 2021;30(2):110-112 PMID: 34082513

Li-Fraumeni syndrome is a rare disorder caused by abnormalities of the tumor-suppressor protein P53 gene. We present the case of a 26-years-old female diagnosed with bilateral ductal carcinoma. The genetic panel for breast cancer gene 1 (BRCA1) and BRCA2 mutations was negative and positive heterozygous germline tumor protein P53 gene mutations, considering Li-Fraumeni syndrome. A 2-[18F]-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) was used for postsurgical staging to show the right lung hypermetabolic nodule. A lobectomy was accomplished, and histopathology reported pulmonary adenocarcinoma. A year later, oncological follow-up was conducted with 2-[18F]-FDG PET/CT without evidence of abnormalities.

Keywords: Li-Fraumeni syndrome, positron emission tomography, fluorodeoxyglucose 18F


Informed Consent: Informed consent was obtained from patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: M.A.H., I.F.V.G., L.L.V., C.M.A., Concept: M.A.H., I.F.V.G., Design: M.A.H., I.F.V.G., Data Collection or Processing: M.A.H., I.F.V.G., L.L.V., C.M.A., Analysis or Interpretation: M.A.H., I.F.V.G., L.L.V., C.M.A., Literature Search: M.A.H., Writing: M.A.H., I.F.V.G., L.L.V., C.M.A.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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