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Incidental Hydroxyapatite Ocular Implant Uptake on Bone Scan Done for Prostate Cancer Staging: Case Report and Brief Review


  • Guillaume Chaussé
  • Jerome Laufer
  • Gad Abikhzer
  • Stephan Probst

Received Date: 01.11.2018 Accepted Date: 26.03.2019 Mol Imaging Radionucl Ther 2019;28(2):86-88 PMID: 31237141

A 74-year-old man recently diagnosed with high-risk prostate cancer with high serum prostate specific antigen was referred to nuclear medicine for a technetium-99m-methylene diphosphonate (Tc-99m MDP) bone scan. On delayed three-hour anterior planar image, an unexpected round focus of intense uptake was found overlying the right orbit. Single-photon emission computed tomography/computed tomography localized the uptake to an ocular prosthesis. The hydroxyapatite composition of the ocular implant can be recognized by its bone-like density and its intense accumulation of Tc-99m MDP. Review of the patient’s history revealed remote right eye evisceration secondary to a complication of cataract surgery, consistent with the findings.

Keywords: Tc-99m MDP, bone scan, ocular implant, artificial eye, eye prosthesis, hydroxyapatite


Informed Consent: Consent form was filled out by all participants.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: G.C., J.L., G.A., S.P., Concept: G.C., J.L., G.A., S.P., Design: G.C., J.L., G.A., S.P., Data Collection or Processing: G.C., J.L., G.A., S.P., Analysis or Interpretation: G.C., J.L., G.A., S.P., Literature Search: G.C., J.L., G.A., S.P., Writing: G.C., J.L., G.A., S.P.

Conflict of Interest:No conflict of interest was declared by the authors.

Financial Disclosure:The authors declared that this study received no financial support.


  1. Gradinaru S, Popescu V, Leasu C, Pricopie S, Yasin S, Ciuluvica R, Ungureanu E. Hydroxyapatite ocular implant and non-integrated implants in eviscerated patients. J Med Life 2015;8:90-93.
  2. Civelek AC, Pacheco EM, Natarajan TK, Wagner HN Jr, Iliff NT. Quantitative measurement of vascularization and vascular in growth rate of coralline hydroxyapatite ocular implant by Tc-99m MDP bone imaging. Clin Nucl Med 1995;20:779-787.
  3. Numerow LM, Kloiber R, Mitchell RJ, Molnar CP, Anderson MA. Hydroxyapatite orbital implants. Scanning with technetium-99m MDP. Clin Nucl Med 1994;19:9-12.
  4. Menzel C, Grünwald F, Busin M, Mönks T, Hotze AL, Schomburg A, Pavics L, Biersack HJ. Vascularisation of ocular coralline hydroxyapatite implants. Eur J Nucl Med 1994;21:1343-1345.
  5. Leitha T, Staudenherz A, Scholz U. Three-phase bone scintigraphy of hydroxyapatite ocular implants. Eur J Nucl Med 1995;22:308-314.