Interesting Image

Mild ⁶⁸Ga PSMA-11 Uptake in Incidental Pituitary Adenoma

10.4274/mirt.galenos.2021.97752

• Ediz Beyhan
• Özge Erol Fenercioğlu
• Yeşim Karagöz
• Nurhan Ergül
• Tevfik Fikret Çermik

Received Date: 10.07.2021 Accepted Date: 10.07.2021 Mol Imaging Radionucl Ther 2022;31(3):244-245 PMID: 36268938

• Abstract
• Full Text
• Video - Image
• References
• 1
• 474

A 76-year-old man with metastatic prostate cancer was referred to ⁶⁸Ga prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) for restaging. A consecutive ¹⁸F-fluorodeoxyglucose (FDG) PET/CT was performed due to the history of lung cancer in the left lung treated with stereotactic radiotherapy. Intense ¹⁸F-FDG uptake was detected in the pituitary gland despite the mild uptake of ⁶⁸Ga PSMA. Contrast-enhanced magnetic resonance imaging confirmed pituitary adenoma.

Keywords: 68Ga PSMA PET/CT, pituitary adenoma, 18F-FDG PET/CT

Ethics

Informed Consent: Obtained from the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Concept: T.F.Ç., N.E., Design: T.F.Ç., N.E., Data Collection or Processing: Y.K., Ö.E.F., E.B., Analysis or Interpretation: T.F.Ç., N.E., Literature Search: E.B., T.F.Ç., N.E., Writing: E.B., Y.K., Ö.E.F., T.F.Ç., N.E.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

Images

1. Jeong SY, Lee SW, Lee HJ, Kang S, Seo JH, Chun KA, Cho IH, Won KS, Zeon SK, Ahn BC, Lee J. Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study. Eur J Nucl Med Mol Imaging 2010;37:2334-2343.
2. Maffei P, Marzola MC, Musto A, Dassie F, Grassetto G, De Carlo E, Rampin L, Chondrogiannis S, Massaro A, Pelizzo MR, Rubello D. A very rare case of nonfunctioning pituitary adenoma incidentally disclosed at 18F-FDG PET/CT. Clin Nucl Med 2012;37:e100-e101.
3. Hyun SH, Choi JY, Lee KH, Choe YS, Kim BT. Incidental focal 18F-FDG uptake in the pituitary gland: clinical significance and differential diagnostic criteria. J Nucl Med 2011;52:547-550.
4. Bashari WA, Senanayake R, Fernández-Pombo A, Gillett D, Koulouri O, Powlson AS, Matys T, Scoffings D, Cheow H, Mendichovszky I, Gurnell M. Modern imaging of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 2019;33:101278.
5. Sheikhbahaei S, Afshar-Oromieh A, Eiber M, Solnes LB, Javadi MS, Ross AE, Pienta KJ, Allaf ME, Haberkorn U, Pomper MG, Gorin MA, Rowe SP. Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging. Eur J Nucl Med Mol Imaging 2017;44:2117-2136.
6. Bilgin R, Ergül N, Çermik TF. Incidental meningioma mimicking metastasis of prostate adenocarcinoma in 68Ga-labeled PSMA ligand PET/CT. Clin Nucl Med 2016;41:956-958.
7. Strele-Trieb P, Dunzinger A, Sonnberger M, Wolfsgruber J, Pichler R. Uptake of 68Ga-prostate-specific membrane antigen PET in adrenal gland: a potential pitfall. Clin Nucl Med 2018;43:50-51.
8. Pfob CH, Karimov I, Jesinghaus M, Novotny A, Weber WA, Eiber M, Feuerecker B. Pitfalls in Ga-68-PSMA-PET/CT: incidental finding of parathyroid adenoma. Eur J Nucl Med Mol Imaging 2019;46:1041.