Interesting Image

Mickey Mouse Sign on Bone Scan in the Monostotic Form of Paget’s Disease Mimicking Osseous Metastasis


  • Selin Kesim
  • Halil Turgut Turoğlu
  • Salih Özgüven
  • Tunç Öneş
  • Tanju Yusuf Erdil

Received Date: 05.09.2019 Accepted Date: 22.11.2019 Mol Imaging Radionucl Ther 2020;29(3):132-134 PMID: 33094577

Paget’s disease is a chronic benign bone disease characterized by excessive and abnormal bone remodeling. Monostotic Paget’s disease accounts for only 20% of the cases, and the monostotic form involving the vertebra with the Mickey Mouse sign is very rare. Herein, we report a case of suspected bony metastasis in the second lumbar vertebra that was diagnosed as Paget’s disease because of the Mickey Mouse sign on bone scintigraphy, and the diagnosis was confirmed by biopsy. Therefore, bone scintigraphy may provide a positive contribution to the diagnosis, and may help to avoid unnecessary biopsy in cases with specific signs and patterns.

Keywords: Paget’s disease, monostotic Paget’s disease, spine, Mickey Mouse sign, technetium 99m-methylene diphosphonate bone scintigraphy, SPECT/CT


Informed Consent: We have obtained all appropriate patient consent forms. In the form the patient has given her consent for her images and other clinical information to be reported in the journal.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: S.K., Concept: H.T.T., S.Ö., Design: T.Ö., T.Y.E., Data Collection or Processing: S.K., Analysis or Interpretation: H.T.T., Literature Search: H.T.T., Writing: S.K., H.T.T.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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