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Long-term Intense 18F-FDG Uptake by the Homeostatic Matrix-associated Inflammatory Response May Mimic Malignancy Recurrence


  • Fatih Tamer
  • Bülent Yazıcı
  • Aylin Oral
  • Ayşegül Akgün

Received Date: 12.01.2023 Accepted Date: 04.02.2023 Mol Imaging Radionucl Ther 2023;32(3):233-236 PMID: 37870300

A 70-year-old man underwent right upper lobectomy for lung adenocarcinoma. During the operation, hemostatic matrix (as known Floseal®) was used to prevent pulmonary laceration-associated bleeding. When 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography was performed for staging after surgery, intense 18F-FDG uptake was observed in the cicatricial fibrotic tissue in the operation area, and no significant change was observed in that area during the 4-year follow-up. Because it remained stable for several years without treatment, this finding was thought to be due to a foreign body reaction caused by the homeostatic material.

Keywords: Homeostatic matrix, false positivity, positron emission tomography, lung cancer


Informed Consent: Informed consent was obtained from the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: F.T., B.Y., A.O., A.A., Concept: F.T., B.Y., A.O., A.A., Design: F.T., B.Y., A.O., A.A., Data Collection or Processing: F.T., A.A., Analysis or Interpretation: F.T., B.Y., A.O., A.A., Literature Search: F.T., A.A., Writing: F.T., A.A.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support.


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