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Detection of Squamous Cell Carcinoma Foci in a Patient with Dystrophic Epidermolysis Bullosa in 18F-FDG PET/CT


  • Esra Arslan
  • Tevfik Fikret Çermik
  • Ayşe Esra Koku Aksu
  • Mehmet Salih Gürel
  • Cem Leblebici

Received Date: 21.07.2018 Accepted Date: 12.11.2018 Mol Imaging Radionucl Ther 2019;28(2):79-82 PMID: 31237139

Dystrophic epidermolysis bullosa (DEB) is a rare, inherited skin fragility disorder characterized by blister formation in the sublamina densa. DEB is associated with aggressive squamous cell carcinoma (SCC) that has increased risk of metastases and poor prognosis. A 41-year-old woman with DEB underwent 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/BT). PET/CT showed increased 18F-FDG uptakes in multifocal cutaneous lesions in both lower extremities. The patient was diagnosed with SCC via skin biopsy from the left lateral lower thigh. Ten months later, PET/CT showed increased FDG uptakes in the primary tumor area as well as the left inguinal and left supraclavicular lymph node regions. 18F-FDG PET/CT seems to be useful for re-staging and planning appropriate therapeutic strategy in DEB-patients with SCC.

Keywords: 18F-FDG PET/CT, dystrophic epidermolysis bullosa, squamous cell carcinoma


Informed Consent: Consent form was filled out by all participants.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Concept: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Design: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Data Collection or Processing: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Analysis or Interpretation: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Literature Search: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L., Writing: E.A., T.F.Ç., A.E.K.A., M.S.G., C.L.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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