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Cutaneous Metastase of Rectal Neuroendocrine Carcinoma Revealed on ¹⁸F-FDG PET/CT

10.4274/mirt.galenos.2022.99266

• Ömer Faruk Şahin
• Rahime Şahin
• Mehmet Can Baloğlu
• Tevfik Fikret Çermik
• Nurhan Ergül

Received Date: 09.08.2022 Accepted Date: 04.10.2022 Mol Imaging Radionucl Ther 2023;32(2):153-155 PMID: 37337847

• Abstract
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Rectal neuroendocrine carcinomas constitute <1% of all neuroendocrine carcinomas and <1% of all gastrointestinal tract malignancies. Cutaneous metastases of rectal neuroendocrine carcinoma are rarer than visceral metastases. We represent a 71-year-old man who was diagnosed with neuroendocrine tumor grade 3 originating from the rectum 1 year ago. He was referred for ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography for restaging after 6 cycles of chemotherapy and radiotherapy. Intensely increased ¹⁸F-FDG uptake in the right cutaneous inguinal region was consistent with neuroendocrine carcinoma metastasis with biopsy from the same region.

Keywords: 18F-FDG-PET, rectal neuroendocrine carcinoma, cutaneous metastasis

Ethics

Informed Consent: The patient consent was obtained.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Concept: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Design: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Data Collection or Processing: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Analysis or Interpretation: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Literature Search: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E., Writing: Ö.M.Ş., R.Ş., M.C.B., T.F.Ç., N.E.

Conflict of Interest: No conflict of interest was declare by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

Images

1. Voong KR, Rashid A, Crane CH, Minsky BD, Krishnan S, Yao JC, Wolff RA, Skibber JM, Feig BW, Chang GJ, Das P. Chemoradiation for high-grade neuroendocrine carcinoma of the rectum and anal canal. Am J Clin Oncol 2015;40:555-560.
2. Müller-Richter UDA, Gesierich A, Kübler AC, Hartmann S, Brands RC. Merkel cell carcinoma of the head and neck: recommendations for diagnostics and treatment. Ann Surg Oncol 2017;24:3430-3437.
3. Amorim GM, Quintella D, Cuzzi T, Rodrigues R, Ramos-E-Silva M. Cutaneous metastasis of neuroendocrine carcinoma with unknown primary site: case report and review of the literature. Case Rep Dermatol 2015;7:263-274.
4. Aldret S, Cotton L. Skin as a site of metastasis. Osteopathic Family Physician 2012;4:13-17.
5. Fluehler C, Quaranta L, di Meo N, Ulessi B, Trevisan G. Cutaneous metastasis of neuroendocrine carcinoma. Indian J Dermatol 2013;58:247.
6. 6.Lee WJ, Oh SH, Chang SE, Lee MW. Skin Metastasis of neuroendocrine carcinoma arising in the rectum. Ann Dermatol 2007;19:163-165.
7. Bell HK, Poston GJ, Vora J, Wilson NJ. Cutaneous manifestations of the malignant carcinoid syndrome. Br J Dermatol 2005;152:71-75.
8. Wang SM, Ye M, Ni SM. Multiple scalp metastases from colonic neuroendocrine carcinoma: case report and literature review. BMC Cancer 2014;14:305.