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Alterations in 18F-FDG Uptake Patterns may Limit Cross-sectional Evaluation of Adrenal Adenomas Using Single 18F-FDG PET/CT Imaging


  • Fatih Tamer
  • Ülkem Yararbaş

Received Date: 11.01.2023 Accepted Date: 01.03.2023 Mol Imaging Radionucl Ther 2023;32(3):247-249 PMID: 37870385

Adrenal adenomas are observed in up to 7% of the population and are predominantly non-functional, increased 18F-fluorodeoxyglucose (FDG) uptake is seen in only a small portion of them on 18F-FDG positron emission tomography/computed tomography (PET/CT) imaging. In this report, we present the sequential 18F-FDG PET/CT imaging findings of 2 patients with radiologically or pathologically confirmed adrenal adenomas who had severely altered 18F-FDG uptake patterns in adrenal lesions in different imaging studies of the same patient. In light of these findings, we wanted to highlight that evaluating adrenal adenomas as cross-sectional with semi-quantitative PET/CT parameters obtained from single imaging may cause misinterpretation.

Keywords: Adrenal adenoma, 18F-FDG, positron emission tomography


Informed Consent: Patient consent was obtained.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: F.T., Ü.Y., Concept: F.T., Ü.Y., Design: F.T., Ü.Y., Data Collection or Processing: F.T., Ü.Y., Analysis or Interpretation: F.T., Ü.Y., Literature Search: F.T., Ü.Y., Writing: F.T., Ü.Y.

Conflict of Interest: No conflict of interest was declare by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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