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Almost Complete Response with a Single Administration ²²⁵Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary

10.4274/mirt.galenos.2022.64497

• Nalan Alan Selçuk
• Emre Demirci
• Meltem Ocak
• Türkay Toklu
• Selçuk Ergen
• Levent Kabasakal

Received Date: 30.07.2021 Accepted Date: 07.01.2022 Mol Imaging Radionucl Ther 2022;31(2):139-141 PMID: 35771003

• Abstract
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Neuroendocrine tumors (NETs) are being seen increasingly frequently, and the only known curative treatment method is surgical resection. Peptide receptor radionuclide therapy (PRRT) is a treatment option that the most contributes to progression-free survival and overall survival in metastatic cases.β-emitting radionuclides are traditionally used for PRRT. Nowadays, alpha particle-emitting radionuclides are being developed, with advantages in terms of very high energy and a short path length, which should theoretically show higher efficacy. In this case; in a patient with NET diagnosis who had multiple (>50) lesions in the abdomen, almost all the lesions disappeared with a single dose application. This paper aims to present a case in which we observed the efficacy of ²²⁵Ac-DOTATATE treatment, which is an alpha treatment.

Keywords: 225Ac targeted alpha therapy, neuroendocrine tumors, peptide receptor radionuclide therapy

Ethics

Informed Consent: Obtained from the patient.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: L.K., N.A.S., E.D., Concept: L.K., Design: N.A.S., E.D., Data Collection or Processing: E.D., T.T., M.O., S.E., Analysis or Interpretation: T.T., M.O., Literature Search: T.T., M.O., Writing: L.K., N.A.S., E.D., T.T., M.O.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

Images

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