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A Rare Case of Pulmonary Alveolar Microlithiasis with Diffuse Lung Uptake on Bone Scintigraphy


  • Ahmet Eren Şen
  • Özlem Şahin
  • Zeynep Aydın
  • Buğra Kaya
  • Çağlagül Erol

Received Date: 11.12.2020 Accepted Date: 31.01.2021 Mol Imaging Radionucl Ther 2022;31(2):151-153 PMID: 35771040

Pulmonary alveolar microlithiasis is a rare disease characterized by accumulating intraalveolar small calcium phosphate stones. The disease is slow and does not show any signs in the early stages, but the shortness of breath, cough, and right heart failure may develop as it progresses. Methylene diphosphonate used in bone scintigraphy shows high uptake of calcium deposits in the alveoli and causes diffuse increased radiopharmaceutical uptake in the lungs.

Keywords: Pulmonary alveolar microlithiasis, MDP, bone scintigraphy


Informed Consent: Written informed consent was obtained.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: A.E.Ş., Z.A., Concept: Ö.Ş., Design: Ö.Ş., B.K., Data Collection or Processing: A.E.Ş., Ç.E., Analysis or Interpretation: Ö.Ş., B.K., Literature Search: A.E.Ş., Z.A., Ç.E., Writing: A.E.Ş., Ö.Ş., B.K.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


  1. Kashyap S, Mohapatra PR. Pulmonary alveolar microlithiasis. Lung India 2013;30:143-147.
  2. Alkhankan E, Yamin H, Bukamur H, Alkhankan F, Shweihat Y, Zeid F. Pulmonary alveolar microlithiasis diagnosed with radiography, CT, and bone scintigraphy. Radiol Case Rep 2019;14:775-777.
  3. Arpağ H, Sayan M, Atilla N, Bozkuş F, Bahar AY, Kahraman H, Tokur M. A case of pulmonary alveolar microlithiasis diagnosed by transbronchial biopsy. Turk Thorac J 2017;18:134-136.
  4. Simon CT, Lewis TC, Neemuchwala F, Arteta M, Rabah R. Pulmonary alveolar microlithiasis: a case report with a novel mutation in the SLC34A2 gene and review of the literature. Human Pathology: Case Reports 2018;13:33-35.
  5. Ferreira Francisco FA, Pereira e Silva JL, Hochhegger B, Zanetti G, Marchiori E. Pulmonary alveolar microlithiasis. State-of-the-art review. Respir Med 2013;107:1-9.
  6. Castellana G, Castellana G, Gentile M, Castellana R, Resta O. Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide. Eur Respir Rev 2015;24:607-620.
  7. Basu S, Shah M, Joshi JM, Lad S. Imaging calcific concretions of pulmonary alveolar microlithiasis with PET: insight into disease pathophysiology. Clin Nucl Med 2012;37:707-708.
  8. Tanrıkulu AÇ, Dağlı AC, Şenyiğit A, Nazaroğlu H, Babayiğit C. Pulmonary alveolar microlithiasis: radiologic findings of eight cases in Turkey. Turkiye Klinikleri J Med Sci 2010;30:713-720.