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A Case with 68Ga-FAPI Positive and 18F-FDG Negative Breast Cancer


  • Halil Kömek
  • Cihan Gündoğan
  • Hülya Etem
  • Canan Can

Received Date: 18.05.2021 Accepted Date: 08.07.2021 Mol Imaging Radionucl Ther 2021;30(3):201-204 PMID: 34661066

A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent 18flourine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in 18F-FDG PET/CT. Later, gallium-68 (68Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes that 68Ga-FAPI PET/CT imaging is superior to 18F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by 18F-FDG in breast-cancer staging in the future.

Keywords: 68Ga-FAPI, 18F-FDG, PET/CT, breast cancer


Informed Consent: Written informed consent was obtained from the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: H.K., C.G., H.E., C.C., Concept: H.K., C.G., H.E., C.C., Design: H.K., C.G., H.E., C.C., Data Collection or Processing: H.K., C.G., H.E., C.C., Analysis or Interpretation: H.K., C.G., H.E., C.C., Literature Search: H.K., C.G., H.E., C.C., Writing: H.K., C.G., H.E., C.C.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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