Multiple Bone Involvement in Low-grade Myofibroblastic Sarcoma Demonstrated on <sup>18</sup>F-FDG PET/CT
PDF
Cite
Share
Request
Interesting Image
P: 206-208
October 2024

Multiple Bone Involvement in Low-grade Myofibroblastic Sarcoma Demonstrated on 18F-FDG PET/CT

Mol Imaging Radionucl Ther 2024;33(3):206-208
1. Peking University Third Hospital Department of Nuclear Medicine, Beijing, China
No information available.
No information available
Received Date: 26.09.2023
Accepted Date: 25.03.2024
Online Date: 07.10.2024
Publish Date: 07.10.2024
PDF
Cite
Share
Request

Abstract

A 68-year-old woman with low back pain for 2 months was admitted. T2-weighted fat-saturated imaging revealed hyperintense lesions in multiple lumbar regions, suggesting the possibility of bone metastases. Multiple osteolytic and mixed osteolytic-osteoblastic lesions with significant 18F-fluorodeoxyglucose (18F-FDG) uptake, as well as multiple osteoblastic lesions with mild 18F-FDG uptake, were observed on subsequent 18F-FDG positron emission tomography/computed tomography without an identifiable primary lesion. This patient was pathologically diagnosed with low-grade myofibroblastic sarcoma (LGMS) after biopsy and surgery. Although multiple bone involvement in LGMS is extremely rare, this case suggests that it should be considered in the differential diagnosis of multiple bone metastases.

References

1
San Miguel P, Fernández G, Ortiz-Rey JA, Larrauri P. Low-grade myofibroblastic sarcoma of the distal phalanx. J Hand Surg Am. 2004;29:1160-1163.
2
Chan JY, Gooi Z, Wong EW, Ng SK, Tong MC, Vlantis AC. Low-grade myofibroblastic sarcoma: A population-based study. Laryngoscope. 2017;127:116-121.
3
Hadjigeorgiou GF, Samaras V, Varsos V. Low-grade myofibroblastic sarcoma of the thoracic spine: report of an extreme rare case. Br J Neurosurg. 2017;31:731-733.
4
Watanabe K, Ogura G, Tajino T, Hoshi N, Suzuki T. Myofibrosarcoma of the bone: a clinicopathologic study. Am J Surg Pathol. 2001;25:1501-1507.
5
Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep. 2013;4:195-199.
6
Wechalekar MD, Ayres O, Farshid G, Clayer M, Cleland LG. Multicentric myofibroblastic sarcoma. BMJ Case Rep. 2014;2014:bcr2013201666.
7
Wang L, Li LX, Chen DQ, Yang L, Li SK, Cheng C. Low-grade Myofibroblastic sarcoma: clinical and imaging findings. BMC Med Imaging. 2019;19:36.
8
Hou W, Su M, Li Q, Tian R. Low-Grade Myofibroblastic Sarcoma Demonstrated on 99mTc-MDP Bone Scan and 18F-FDG PET/CT. Clin Nucl. Med. 2020;45:549-551.
9
Mendoza H, Nosov A, Pandit-Taskar N. Molecular imaging of sarcomas with FDG PET. Skeletal Radiol. 2023;52:461-475.
10
Roberts CC, Kransdorf MJ, Beaman FD, Adler RS, Amini B, Appel M, Bernard SA, Fries IB, Germano IM, Greenspan BS, Holly LT, Kubicky CD, Lo SS, Mosher TJ, Sloan AE, Tuite MJ, Walker EA, Ward RJ, Wessell DE, Weissman BN. ACR Appropriateness Criteria Follow-Up of Malignant or Aggressive Musculoskeletal Tumors. J Am Coll Radiol. 2016;13:389-400.