Introduction

I-131 ablation therapy is widely used for the treatment of well-differentiated thyroid cancer. Post-ablative scan is a sensitive method for diagnosis of metastatic or residual disease. A false-positive finding of I-131 scan may lead to unnecessary surgery or radio-ablation therapy. The purpose of this study was to emphasize the importance of correlative imaging modalities, especially in patients with suspicion of metastasis.

Case Report

A 47-year-old woman was diagnosed as papillary thyroid carcinoma. Total thyroidectomy was performed in our hospital and I-131 ablation therapy was administered four weeks after surgery. The whole-body scanning was performed on the 7th day of ablation and scintigraphy images revealed a focus of increased uptake in the right upper quadrant. Lateral view images of the uptake site showed that the focus was located in the vicinity of the right liver lobe (Figure 1).

The patient was referred to radiology department for correlative abdominal Computed Tomography (CT) and US, to rule out a possible liver metastasis. The CT detected a gallstone in the corresponding area, which was also verified by US (Figure 2). Neither examination identified metastatic disease in the liver or in other abdominal organs.

Literature Review and Discussion

The lungs and bone are the most frequent sites of distant metastases in patients with papillary thyroid carcinoma (1,2,3). Liver metastases are not common, especially in low-risk patients. An unexpected distant metastasis changes the prognosis and therapeutic evaluation of the patient.

There are a lot of causes for false-positive findings on I-131 scan other than those related to the gallbladder, such as inflammatory diseases, radioactive contamination, esophageal pathologies, skin burn, pericardial effusion, renal cyst or even non-thyroidal neoplasms (4,5,6). There are only a couple of case reports on the uptake of I-131 by the gallbladder. Chronic cholecystitis and excretion into the biliary tract were previously reported as rare causes of gallbladder uptake (7,8,9). Additional imaging was performed to exclude such conditions, since liver metastasis was not expected in our patient. Low resolution of I-131 images and the requirement of anatomic correlation were the other important reasons for further imaging.

Gallstone related I-131 uptake might be due to recurrent cholecystitis and organification of iodine in leukocytes around the gallbladder wall (10). Although the patient was asymptomatic, biochemical changes might have occurred at the cellular level during the chronic disease course. This biochemical reaction can be verified by histopathological tissue analysis.

This is the first case report that documents a false-positive uptake of I-131 scan that was associated with an asymptomatic gallstone, and it emphasizes the importance of correlative imaging in gallbladder diseases.

Concept: Kemal Ünal
Design: Kemal Ünal
Data Collection or Processing: Kemal Ünal, Özgür Ümit Akdemir
Analysis or Interpretation: Kemal Ünal, Özgür Ümit Akdemir
Literature Search: Kemal Ünal
Writing: Kemal Ünal
Financial Disclosure: None
Peer-review: Externally peer-reviewed.