Interesting Image

¹⁸F-FDG PET/CT Imaging for Treatment Response Assessment of Cardiac Primitive Neuroectodermal Tumor

10.4274/mirt.galenos.2023.91259

• Mehmet Emin Mavi
• Murat Fani Bozkurt

Received Date: 26.01.2023 Accepted Date: 23.08.2023 Mol Imaging Radionucl Ther 2024;33(1):50-53 PMID: 38390790

• Abstract
• Full Text
• Video - Image
• References
• 2
• 308

Primitive neuroectodermal tumors (PNETs) are rare and aggressive members of the small round cell carcinoma family. Generally, PNETs are classified into two main groups: PNETs of the central nervous system and PNETs of the peripheral nervous system. Herein, we report the therapy response assessment of a rare case of isolated cardiac PNET using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging. Given that physiological cardiac FDG uptake is typically observed, assessing FDG avid lesions in the myocardium presents a challenge for FDG PET/CT. This case holds significance because of the rarity of the disease and the challenging nature of the site for FDG PET/CT imaging.

Keywords: Primitive, neuroectodermal, cardiac, 18F-fluorodeoxyglucose, positron, emission, tomography, treatment, response

Ethics

Informed Consent: Since the information provided is anonymous, obtaining informed consent from the patients was deemed not required.

Authorship Contributions

Surgical and Medical Practices: M.E.M., M.F.B., Concept: M.E.M., M.F.B., Design: M.E.M., M.F.B., Data Collection or Processing: M.E.M., M.F.B., Analysis or Interpretation: M.E.M., M.F.B., Literature Search: M.E.M., M.F.B., Writing: M.E.M., M.F.B.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support.

Images

1. Gao L, Zhu Y, Shi X, Gao Z, Chen X. Peripheral primitive neuroectodermal tumors: A retrospective analysis of 89 cases and literature review. Oncol Lett 2019;18:6885-6890.
2. Vogel H, Fuller GN. Primitive neuroectodermal tumors, embryonal tumors, and other small cell and poorly differentiated malignant neoplasms of the central and peripheral nervous systems. Ann Diagn Pathol 2003;7:387-398.
3. Chhabda S, Carney O, D’Arco F, Jacques TS, Mankad K. The 2016 World Health Organization Classification of tumours of the central nervous system: what the paediatric neuroradiologist needs to know. Quant Imaging Med Surg 2016;6:486-489.
4. Kumar V, Singh A, Sharma V, Kumar M. Primary intracranial dural-based Ewing sarcoma/peripheral primitive neuroectodermal tumor mimicking a meningioma: A rare tumor with review of literature. Asian J Neurosurg 2017;12:351-357.
5. Wang J, Li J, Zhang X, Zhang X, Xiao Y. Primitive neuroectodermal tumor of the pericardium: a case report and literature review. BMC Cardiovasc Disord 2021;21:305.
6. Bae SH, Hwang JH, Da Nam B, Kim HJ, Kim KU, Kim DW, Choi IH. Multiple ewing sarcoma/primitive neuroectodermal tumors in the mediastinum: a case report and literature review. Medicine (Baltimore) 2016;95:e2725.
7. Dong A, Wang Y, Lu J, Zuo C. FDG PET/CT in peripheral primitive neuroectodermal tumor of the retroperitoneum. Clin Nucl Med 2014;39:707-710.
8. Musana KA, Raja S, Cangelosi CJ, Lin YG. FDG PET scan in a primitive neuroectodermal tumor. Ann Nucl Med 2006;20:221-225.
9. Sharma P, Ghosh I, Khan EM. 18F-FDG PET/CT for staging and response evaluation in a rare case of childhood ovarian primitive neuroectodermal tumor. Clin Nucl Med 2021;46:e266-e267.
10. Fan C, Kong D, Tan C, Yang J. Isolated cardiac peripheral primitive neuroectodermal tumor: A case report. Cancer Biol Ther 2017;18:4-7.
11. Chai Y, Huang L, Yue L. Peripheral primitive neuroectodermal tumour of left ventricular wall origin: a rare case. Acta Cardiol 2007;62:523-524.
12. Kath R, Krack A, Schneider C, Katenkamp D, Höffken K. Kardiale Manifestation eines peripheren primitiven neuroektodermalen Tumors (pPNET)--eine Rarität [Cardiac manifestations of peripheral primitive neuroectodermal tumor (pPNET): a rare case]. Dtsch Med Wochenschr 2000;125:1192-1194.
13. Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, Verzijlbergen FJ, Barrington SF, Pike LC, Weber WA, Stroobants S, Delbeke D, Donohoe KJ, Holbrook S, Graham MM, Testanera G, Hoekstra OS, Zijlstra J, Visser E, Hoekstra CJ, Pruim J, Willemsen A, Arends B, Kotzerke J, Bockisch A, Beyer T, Chiti A, Krause BJ; European Association of Nuclear Medicine (EANM). FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging 2015;42:328-354.
14. Maurer AH, Burshteyn M, Adler LP, Steiner RM. How to differentiate benign versus malignant cardiac and paracardiac 18F FDG uptake at oncologic PET/CT. Radiographics 2011;31:1287-1305.