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Magnetic Resonance Imaging Signal Changes Mimicking Bone Metastasis in Patients Receiving Bisphosphonate Therapy

10.4274/mirt.galenos.2020.49091

• İpek Tamsel
• Mehmet Argın
• Ayşegül Akgün

Received Date: 15.03.2020 Accepted Date: 31.05.2020 Mol Imaging Radionucl Ther 2021;30(2):122-125 PMID: 34082517

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Bisphosphonates are inorganic pyrophosphate agents that reduce bone turnover. These agents reduce bone pain and delay skeletal complications, such as fractures in patients with metastatic lytic lesions, malignant-related hypercalcemia, multiple myeloma, Paget’s disease of bone, and osteoporosis. Osteonecrosis, developing in the jaw bones specifically, has been described as a complication associated with the use of bisphosphonates. In this report, we presented osteonecrosis-like magnetic resonance imaging findings that can be confused with bone metastasis in two patients who underwent long-term bisphosphonate treatment and the value of bone scan and ¹⁸flor-fluorodeoxyglucose positron emission tomography/computerized tomography in the differential diagnosis.

Keywords: Bisphosphonate, osteonecrosis, long bone, magnetic resonance imaging, bone scan, 18F-flourodeoxyglucose positron emission tomography/computerized tomography

Ethics

Informed Consent: Consent was obtained from the two cases in the study.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: İ.T., M.A., A.A., Concept: İ.T., M.A., A.A., Design: İ.T., M.A., A.A., Data Collection or Processing: İ.T., M.A., A.A., Analysis or Interpretation: İ.T., M.A., A.A., Literature Search: İ.T., M.A., A.A., Writing: İ.T., M.A., A.A.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

Images

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