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Ileal Neuroendocrin Tumor Metastasis to Breast Diagnosed with Ga-68 DOTATATE PET/CT

10.4274/mirt.galenos.2019.28199

  • Sevda Sağlampınar Karyağar
  • Osman Güven
  • Savaş Karyağar

Received Date: 20.01.2019 Accepted Date: 14.05.2019 Mol Imaging Radionucl Ther 2019;28(3):129-131

Breast metastasis of the well differentiated neuroendocrin tumor (WDNET) of the ileum is very rare. A case of a 62-year-old woman with ileal WDNET, who underwent restaging with Ga-68 DOTATATE PET/CT due to progression of metastatic lesions under the treatment with somatostatin analog and mammalian target of rapamycin inhibitors. Ga-68 DOTATATE PET/CT demonstrated intense increased uptake in the subsantimetric nodular lesion in the upper outer quadrant of the left breast. The histopathologic findings obtained by tru-cut biopsy revealed WDNET metastasis (Ki-67 proliferation index 1%).

Keywords: Ga-68 DOTATATE PET/CT, well differentiated neuroendocrin tumor, breast metastasis

Ethics

Informed Consent: Consent form was filled out by all participants.

Peer-reviewed: Eternally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: S.S.K., S.K., O.G., Concept: S.S.K., S.K., O.G., Design: S.S.K., S.K., O.G., Data Collection or Processing: S.S.K., S.K., O.G., Analysis or Interpretation: S.S.K., S.K., O.G., Literature Search: S.S.K., S.K., O.G., Writing: S.S.K.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

Images

  1. Subramaniam RM, Bradshaw LM, Lewis K, Pinho D, Shah C, Walker RC. ACR Practice parameter for the performance of Gallium-68 DOTATATE PET/CT for neuroendocrin tumors. Clin Nucl Med 2018;43:899-908.
  2. Modlin IM, Lye KD, Kidd M. A 5 decade analysis of 13,715 carcinoid tumors. Cancer 2003;15:934-959.
  3. Clark BZ, Bhargava R. Metastatic neuoroendocrin tumors to the breast: Diagnostic pitfall with significant clinical implications. AJSP 2017;22:269-274.
  4. Dervishac OA, Renzi AS, Genato R, Xiao PQ, Asarian AP. Neuroendocrin tumor of the breast:is it primary or metastatic? Int J Case Rep Images 2016;7:34-39.
  5. Ahn S, Bhagwandin S, Reindl B, Jaffer S, Bickell N, Labow DM, Scmidt H. Metastatic carcinoid tumor presenting as a breast mass: A case report and review of the literature. Arch Surg Oncol 2016;2:1-5.
  6. Policeni F, Pakalniskis B, Yang L. Occult primary neuroendocrin tumor metastasis to breast detected on screeniig mammogram. J Clin Imaging Sci 2016;6:41.