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Exceptionally Rare Isolated Thyroidal Metastasis of Pulmonary Carcinosarcoma: A Tale of 18F-FDG-positive Thyroid Nodule

10.4274/mirt.galenos.2023.74507

  • Mehmet Emin Mavi
  • Fariba Amini
  • Seyfettin Ilgan

Received Date: 01.08.2023 Accepted Date: 15.10.2023 Mol Imaging Radionucl Ther 2024;33(1):63-65 PMID: 38390824

Pulmonary carcinosarcomas (PCS) are uncommon and aggressive malignant tumors with epithelial and mesenchymal components and have a worse prognosis than other non-small-cell lung cancers. Metastases of non-thyroidal malignancies to the thyroid are rare. We reported a unique case of isolated thyroidal metastasis of PCS and discussed 18F-fluorodeoxyglucose (18F-FDG) positivity in incidentally found thyroid nodules on 18F-FDG positron emission tomography scan.

Keywords: 18F-fluorodeoxyglucose, thyroid, lung, PET/CT, incidental, ultrasonography

Ethics

Informed Consent: Since the information provided is anonymous, obtaining informed consent from the patients was deemed not required.

Authorship Contributions

Analysis or Interpretation: M.E.M., F.A., S.I., Literature Search: M.E.M., F.A., S.I., Writing: M.E.M., F.A., S.I.

Conflict of Interest: No conflicts of interest were declared by the authors.

Financial Disclosure: The authors declare that this study has received no financial support.

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  1. Rossi G, Cavazza A, Sturm N, Migaldi M, Facciolongo N, Longo L, Maiorana A, Brambilla E. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003;27:311-324.
  2. Nixon IJ, Coca-Pelaz A, Kaleva AI, Triantafyllou A, Angelos P, Owen RP, Rinaldo A, Shaha AR, Silver CE, Ferlito A. Metastasis to the thyroid gland: a critical review. Ann Surg Oncol 2017;24:1533-1539.
  3. Saint-Georges F, Terrier P, Sabourin JC, Bonvalot S, De Montpreville V, Ruffie P. [Pulmonary carcinosarcoma with jejunal metastasis: complete response to chemotherapy]. Rev Pneumol Clin 2002;58:249-252.
  4. Arnedillo Muñoz A, Pérez Requena J, Fernández-Berni JJ, León Jiménez A. Carcinosarcoma pulmonar con metástasis cutánea [Pulmonary carcinosarcoma with skin metastasis]. An Med Interna 2002;19:586-568
  5. Chung SR, Choi YJ, Suh CH, Kim HJ, Lee JJ, Kim WG, Sung TY, Lee YM, Song DE, Lee JH, Baek JH. Thyroid incidentalomas detected on 18F-fluorodeoxyglucose positron emission tomography with computed tomography: malignant risk stratification and management plan. Thyroid 2018;28:762-768.
  6. Bertagna F, Treglia G, Piccardo A, Giubbini R. Diagnostic and clinical significance of F-18-FDG-PET/CT thyroid incidentalomas. J Clin Endocrinol Metab 2012;97:3866-3875.
  7. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 2016;26:1-133.
  8. Scappaticcio L, Piccardo A, Treglia G, Poller DN, Trimboli P. The dilemma of 18F-FDG PET/CT thyroid incidentaloma: what we should expect from FNA. A systematic review and meta-analysis. Endocrine 2021;73:540-549.
  9. Pattison DA, Bozin M, Gorelik A, Hofman MS, Hicks RJ, Skandarajah A. 18F-FDG-avid thyroid incidentalomas: the importance of contextual interpretation. J Nucl Med 2018;59:749-755.