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Comparative Findings Between 68Ga-PSMA and 18F-FDG PET/CT for Hepatocellular Carcinoma


  • Seval Erhamamcı
  • Nesrin Aslan

Received Date: 26.04.2020 Accepted Date: 29.06.2020 Mol Imaging Radionucl Ther 2020;29(3):135-138 PMID: 33094578

We have reported here the case of a 69-year-old man who presented with spinal cord compression due to bone metastases as the first manifestation of hepatocellular carcinoma (HCC). For the initial staging, the patient underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) imaging, which demonstrated mild 18F-FDG uptake in the multiple expansile osteolytic bone lesions, but no remarkable atypical 18F-FDG uptake in the liver lesion on low-doses CT. An additional PET/CT scan was performed to evaluate the prostate-specific membrane antigen (PSMA) expression, which has recently been reported to be a potential biological marker in a variety of tumors including HCC. High PSMA uptake was recorded in both the metastatic bone lesions and the primary liver lesion/tumor by the 68Ga-PSMA PET/CT.

Keywords: Hepatocellular carcinoma, bone metastases, PET/CT, 68Ga-PSMA, 18F-FDG


Informed Consent: Informed consent was taken.

Peer-review: Externally and internally peer-reviewed.

Authorship Contributions

Concept: S.E., Design: S.E., Data Collection or Processing: S.E., N.A., Analysis or Interpretation: S.E., N.A., Literature Search: S.E., Writing: S.E.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


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